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验证数据展示

  • WB analysis using 16168-1-AP (same clone as 16168-1-PBS)

    WB analysis using 16168-1-AP (same clone as 16168-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 16168-1-AP (PSEN2-Specific antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 16168-1-PBS in a different storage buffer formulation.

  • WB analysis of A549 using 16168-1-AP (same clone as 16168-1-PBS)

    WB analysis of A549 using 16168-1-AP (same clone as 16168-1-PBS)

    WB result of PSEN2-Specific antibody (16168-1-AP; 1:1200; incubated at room temperature for 1.5 hours) with sh-Control and sh-PSEN2-Specific transfected A549 cells. This data was developed using the same antibody clone with 16168-1-PBS in a different storage buffer formulation.

  • IHC staining of human kidney using 16168-1-AP (same clone as 16168-1-PBS)

    IHC staining of human kidney using 16168-1-AP (same clone as 16168-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human kidney tissue slide using 16168-1-AP (PSEN2-Specific Antibody) at dilution of 1:200 (under 10x lens). This data was developed using the same antibody clone with 16168-1-PBS in a different storage buffer formulation.

  • IHC staining of human kidney using 16168-1-AP (same clone as 16168-1-PBS)

    IHC staining of human kidney using 16168-1-AP (same clone as 16168-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human kidney tissue slide using 16168-1-AP (PSEN2-Specific Antibody) at dilution of 1:200 (under 40x lens). This data was developed using the same antibody clone with 16168-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO验证

PSEN2-Specific Polyclonal antibody, PBS Only

PSEN2-Specific Polyclonal Antibody for WB, IHC, ELISA
Cat No. 16168-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, ELISA

别名

PSEN2, E5-1, EC:3.4.23.-, Presenilin 2, Presenilin-2

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

16168-1-PBS targets PSEN2-Specific in WB, IHC, ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

Peptide

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 presenilin 2 (Alzheimer disease 4)
别名 PSEN2, E5-1, EC:3.4.23.-, Presenilin 2, Presenilin-2
计算分子量 50 kDa
观测分子量55-60 kDa
GenBank蛋白编号NM_000447
基因名称 PSEN2
Gene ID (NCBI) 5664
RRIDAB_2170748
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDP49810
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Presenilins can regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. These transmembrane proteins are considered to be involved in early onset of Alzheimer's disease. Presenilin 2 mainly localizes in large neurons. It exists in a heterodimeric complex formed from the endoproteolytically processed amino-terminal (34 kDa) and carboxy-terminal (about 23 kDa) fragments.This antibody is specific to presenilin 2. It will not bind presenilin 1.

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