验证数据展示
产品信息
68621-1-PBS targets PRODH in WB, Indirect ELISA applications and shows reactivity with Human, mouse, rat, rabbit, pig samples.
| 经测试应用 | WB, Indirect ELISA Application Description |
| 经测试反应性 | Human, mouse, rat, rabbit, pig |
| 免疫原 | PRODH fusion protein Ag18429 种属同源性预测 |
| 宿主/亚型 | Mouse / IgG1 |
| 抗体类别 | Monoclonal |
| 产品类型 | Antibody |
| 全称 | proline dehydrogenase (oxidase) 1 |
| 别名 | FLJ33744, HSPOX2, p53 induced gene 6 protein, PIG6, POX, POX2, PRODH, PRODH1, PRODH2, Proline oxidase, Proline oxidase 2, SCZD4, TP53I6 |
| 计算分子量 | 600 aa, 68 kDa |
| 观测分子量 | 56 kDa, 66 kDa |
| GenBank蛋白编号 | BC118597 |
| 基因名称 | PRODH |
| Gene ID (NCBI) | 5625 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein G purification |
| UNIPROT ID | O43272 |
| 储存缓冲液 | PBS only , pH 7.3 |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
PRODH(Proline dehydrogenase 1, mitochondrial) is also named as PIG6, HSPOX2, PRODH1, PRODH2, POX, SCZD4, TP53I6 and belongs to the proline oxidase family. It is an oxidoreductase involved in the transfer of redox potential across the mitochondrial membrane and catalyzes the rate-limiting oxidation of proline to pyrroline- 5-carboxylate (P5C). High PRODH activity is sufficient to induce mitochondria-mediated apoptosis in the presence of proline. Defects in PRODH are the cause of hyperprolinemia type 1 (HP-1) and defects in PRODH are associated with susceptibility to schizophrenia type 4 (SCZD4). This protein has 3 isoforms produced by alternative splicing with the molecular mass of 68 kDa, 59 kDa and 56 kDa.