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验证数据展示

  • IHC staining of mouse embryo using 11743-1-AP (same clone as 11743-1-PBS)

    IHC staining of mouse embryo using 11743-1-AP (same clone as 11743-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse embryo tissue slide using 11743-1-AP (PKIA antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 11743-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with PKIA antibody included
  • IHC staining of mouse embryo using 11743-1-AP (same clone as 11743-1-PBS)

    IHC staining of mouse embryo using 11743-1-AP (same clone as 11743-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse embryo tissue slide using 11743-1-AP (PKIA antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 11743-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with PKIA antibody included
  • IHC staining of mouse brain using 11743-1-AP (same clone as 11743-1-PBS)

    IHC staining of mouse brain using 11743-1-AP (same clone as 11743-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 11743-1-AP (PKIA antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 11743-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with PKIA antibody included
  • IHC staining of mouse brain using 11743-1-AP (same clone as 11743-1-PBS)

    IHC staining of mouse brain using 11743-1-AP (same clone as 11743-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 11743-1-AP (PKIA antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 11743-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with PKIA antibody included
  • IF Staining of HeLa using 11743-1-AP (same clone as 11743-1-PBS)

    IF Staining of HeLa using 11743-1-AP (same clone as 11743-1-PBS)

    Immunofluorescent analysis of (-20°C Methanol) fixed HeLa cells using PKIA antibody (11743-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). This data was developed using the same antibody clone with 11743-1-PBS in a different storage buffer formulation.

PKIA Polyclonal antibody, PBS Only

PKIA Polyclonal Antibody for IHC, IF/ICC, Indirect ELISA
Cat No. 11743-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

IHC, IF/ICC, Indirect ELISA

别名

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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Planning an IHC experiment? We recommend our IHCeasy PKIA Ready-To-Use IHC Kit. PKIA primary antibody included.

产品信息

11743-1-PBS targets PKIA in IHC, IF/ICC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 IHC, IF/ICC, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag2338

Product name: Recombinant human PKIA protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-76 aa of BC022265

Sequence: MTDVETTYADFIASGRTGRRNAIHDILVSSASGNSNELALKLAGLDINKTEGEEDAQRSSTEQSGEAQGEAAKSES

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 protein kinase (cAMP-dependent, catalytic) inhibitor alpha
别名
计算分子量 76 aa, 8 kDa
GenBank蛋白编号BC022265
基因名称 PKIA
Gene ID (NCBI) 5569
RRIDAB_3085380
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDP61925
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

cAMP-dependent protein kinase inhibitor alpha (PKIA) is also named as PRKACN1, and belongs to the PKI family. Among them, PKIA, a member of protein kinase A (PKA) inhibitor family, was found to be most significantly and highly expressed in susceptible animals (PMID:24910983). Decreased PKIA signaling would directly impact PKA activation, potentially inducing DRP1 phosphorylation and increasing ER Ca2+ stores (PMID:32152556). miR-129-5p activated PKA to regulate the phosphorylation of beta-catenin and cAMP-response element binding protein (CREB) by inhibiting PKIA (PMID:36222334).

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