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验证数据展示

  • WB analysis using 87233-1-RR (same clone as 87233-1-PBS)

    WB analysis using 87233-1-RR (same clone as 87233-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 87233-1-RR (PFKFB3 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 87233-1-PBS in a different storage buffer formulation.

  • IF Staining of A549 using 87233-1-RR (same clone as 87233-1-PBS)

    IF Staining of A549 using 87233-1-RR (same clone as 87233-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed A549 cells using PFKFB3 antibody (87233-1-RR, Clone: 252490B6 ) at dilution of 1:800 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2), CL594-Phalloidin (red). This data was developed using the same antibody clone with 87233-1-PBS in a different storage buffer formulation.

  • Affinity of 87233-1-RR

    Affinity of 87233-1-RR

    Biolayer interferometry (BLl) kinetic assays of 87233-1-RR against Human PFKFB3 were performed. The affinity constant is 0.227 nM.

PFKFB3 Recombinant monoclonal antibody, PBS Only

PFKFB3 Uni-rAb® Recombinant Antibody for WB, IF/ICC, Indirect ELISA
Cat No. 87233-1-PBS

产品说明书

CloneNo. 252490B6

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IF/ICC, Indirect ELISA

别名

6PF-2-K/Fru-2,6-P2ase 3, 6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme, 6-phosphofructo-2-kinase, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3, Fructose-2,6-bisphosphatase

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

87233-1-PBS targets PFKFB3 in WB, IF/ICC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IF/ICC, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag4744

Product name: Recombinant human PFKFB3 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 243-520 aa of BC040482

Sequence: HVQPRTIYLCRHGENEHNLQGRIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEEYALREQDKYYYRYPTGESYQDLVQRLEPVIMELERQENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKLTPVAYGCRVESIYLNVESVCTHRERSEDAKKGPNPLMRRNSVTPLASPEPTKKPRINSFEEHVASTSAALPSCLPPEVPTQLPGQNMKGSRSSADSSRKH

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
别名 6PF-2-K/Fru-2,6-P2ase 3, 6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme, 6-phosphofructo-2-kinase, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3, Fructose-2,6-bisphosphatase
计算分子量 520 aa, 60 kDa
观测分子量58 kDa
GenBank蛋白编号BC040482
基因名称 PFKFB3
Gene ID (NCBI) 5209
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purification
UNIPROT IDQ16875
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

PFKFB3, also named as NY-REN-56 and iPFK-2, plays a role in glucose metabolism. Its synthesis and degradation of fructose 2,6-bisphosphate. Endogenously generated adenosine cooperates with bacterial components to increase PFKFB3 isozyme activity, resulting in greater fructose 2,6-bisphosphate accumulation. PFKFB3 is required for increased growth, metabolic activity and is regulated through active JAK2 and STAT5.

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