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PF-00356231 hydrochloride

CAS号

820223-77-6

分子式

C25H21ClN2O3S

主要靶点

MMP

仅限科研使用

Cat No : CM11007

Print datasheet

Synonyms

MMP-13|MMP13|MMP-12|MMP-3|MMP-8|MMP-9|PF 00356231 hydrochloride|PF 00356231 Hydrochloride|PF00356231 hydrochloride|PF00356231 Hydrochloride|PF-00356231 Hydrochloride

验证数据展示

  • CAS No.: 820223-77-6

    PF-00356231 hydrochloride
    CAS#: 820223-77-6

产品信息

CAS号 820223-77-6
分子式 C25H21ClN2O3S
主要靶点 MMP
主要通路 蛋白酶体
分子量 464.96
纯度 98.07%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 MMP-13|MMP13|MMP-12|MMP-3|MMP-8|MMP-9|PF 00356231 hydrochloride|PF 00356231 Hydrochloride|PF00356231 hydrochloride|PF00356231 Hydrochloride|PF-00356231 Hydrochloride

靶点活性

MMP12:1.4 μM|MMP9:0.98 μM|MMP13:0.65 nM|MMP8:1.7 μM|MMP3:0.39 μM

体外活性

PF-00356231 hydrochloride 对 MMP-13、MMP-3、MMP-9 和 MMP-8 表现出抑制活性，其半抑制浓度（IC50s）分别为 0.65 nM、0.39 μM、0.98 μM 和 1.7 μM。在 AH[1] 存在的条件下，PF-00356231 hydrochloride 能降低 MMP-12（0.014 μM）和 MMP-13（0.27 μM）的 IC50 值。

溶解度

DMSO:18.9 mg/mL (40.6 mM)

参考文献

1.Morales R, et al. Crystal structures of novel non-peptidic, non-zinc chelating inhibitors bound to MMP-12. J Mol Biol. 2004 Aug 20;341(4):1063-76.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2