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验证数据展示

  • IHC staining of mouse skeletal muscle using 84425-5-RR (same clone as 84425-5-PBS)

    IHC staining of mouse skeletal muscle using 84425-5-RR (same clone as 84425-5-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse skeletal muscle tissue slide using 84425-5-RR (PERM1 antibody) at dilution of 1:500 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 84425-5-PBS in a different storage buffer formulation.

  • IHC staining of mouse skeletal muscle using 84425-5-RR (same clone as 84425-5-PBS)

    IHC staining of mouse skeletal muscle using 84425-5-RR (same clone as 84425-5-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse skeletal muscle tissue slide using 84425-5-RR (PERM1 antibody) at dilution of 1:500 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 84425-5-PBS in a different storage buffer formulation.

  • IF Staining of H9C2 using 84425-5-RR (same clone as 84425-5-PBS)

    IF Staining of H9C2 using 84425-5-RR (same clone as 84425-5-PBS)

    Immunofluorescent analysis of (4% PFA) fixed H9C2 cells using PERM1 antibody (84425-5-RR, Clone: 241613B6 ) at dilution of 1:250 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2), CL594-Phalloidin (red). This data was developed using the same antibody clone with 84425-5-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84425-5-RR

    Affinity and Kinetic Characterization of 84425-5-RR

    Biolayer interferometry (BLl) kinetic assays of 84425-5-RR against Human PERM1 were performed. The affinity constant is below 1 pM.

PERM1 Recombinant monoclonal antibody, PBS Only

PERM1 Uni-rAb® Recombinant Antibody for IHC, IF/ICC, Indirect ELISA
Cat No. 84425-5-PBS

产品说明书

CloneNo. 241613B6

宿主/亚型

Rabbit / IgG

种属反应性

human, rat

应用

IHC, IF/ICC, Indirect ELISA

别名

C1orf170, PERM, 241613B6

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

84425-5-PBS targets PERM1 in IHC, IF/ICC, Indirect ELISA applications and shows reactivity with human, rat samples.

经测试应用 IHC, IF/ICC, Indirect ELISA Application Description
经测试反应性 human, rat
免疫原

CatNo: Ag23833

Product name: Recombinant human C1orf170 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-58 aa of BC006300

Sequence: MCLVFVAFATWAVRTSDPHTPDAWKTALLANVGTISAIRYFRRQAGQGRRSHSPSPSS

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 chromosome 1 open reading frame 170
别名 C1orf170, PERM, 241613B6
GenBank蛋白编号BC006300
基因名称 C1orf170
Gene ID (NCBI) 84808
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purfication
UNIPROT IDQ5SV97
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

PERM1 (PGC-1/ERR-induced regulator in muscle 1) is a muscle-specific protein induced by PGC-1α and ERRα. PERM1 protein expression is mainly restricted to heart and skeletal muscle, indicating PERM1 functions as a tissue-specific regulator of mitochondrial biogenesis in response to exercise (PMID: 33549681, 36028747). Ablation of Perm1 in mice results in reduced protein expression of lipin-1 accompanied by accumulation of specific phospholipid species (PMID: 33549681). There are two major isoforms of Perm1 protein, the short isoform is about 85 kDa, and the long isoform is 105 kDa.

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