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Host
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Species Reactivity
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Species Reactivity
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Conjugate
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Compatible Species
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Conjugate
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验证数据展示

  • WB analysis of Jurkat using 67565-1-Ig (same clone as 67565-1-PBS)

    WB analysis of Jurkat using 67565-1-Ig (same clone as 67565-1-PBS)

    Jurkat cells were subjected to SDS PAGE followed by western blot with 67565-1-Ig (PDE6D antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67565-1-PBS in a different storage buffer formulation.

  • WB analysis using 67565-1-Ig (same clone as 67565-1-PBS)

    WB analysis using 67565-1-Ig (same clone as 67565-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 67565-1-Ig (PDE6D antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67565-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse brain using 67565-1-Ig (same clone as 67565-1-PBS)

    IHC staining of mouse brain using 67565-1-Ig (same clone as 67565-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 67565-1-Ig (PDE6D antibody) at dilution of 1:500 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 67565-1-PBS in a different storage buffer formulation.

PDE6D Monoclonal antibody, PBS Only

PDE6D Monoclonal Antibody for WB, IHC, ELISA
Cat No. 67565-1-PBS

产品说明书

CloneNo. 1H4B6

宿主/亚型

Mouse / IgG1

种属反应性

human, mouse, rat, pig

应用

WB, IHC, ELISA

别名

1H4B6, PDED

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

67565-1-PBS targets PDE6D in WB, IHC, ELISA applications and shows reactivity with human, mouse, rat, pig samples.

经测试应用 WB, IHC, ELISA Application Description
经测试反应性 human, mouse, rat, pig
免疫原

CatNo: Ag29563

Product name: Recombinant human PDE6D protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-150 aa of NM_002601

Sequence: MSAKDERAREILRGFKLNWMNLRDAETGKILWQGTEDLSVPGVEHEARVPKKILKCKAVSRELNFSSTEQMEKFRLEQKVYFKGQCLEEWFFEFGFVIPNSTNTWQSLIEAAPESQMMPASVLTGNVIIETKFFDDDLLVSTSRVRLFYV

种属同源性预测
宿主/亚型 Mouse / IgG1
抗体类别 Monoclonal
产品类型 Antibody
全称 phosphodiesterase 6D, cGMP-specific, rod, delta
别名 1H4B6, PDED
计算分子量 17 KDa
观测分子量 15-17 kDa
GenBank蛋白编号NM_002601
基因名称 PDE6D
Gene ID (NCBI) 5147
RRIDAB_2882779
偶联类型 Unconjugated
形式Liquid
纯化方式Protein G purification
UNIPROT IDO43924
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

PDE6D, also known as PDED, belongs to the PDE6D/unc-119 family. PDE6D is a ubiquitously expressed prenyl-binding protein. By binding to prenyl moieties, PDE6D mediates the shuttling of prenylated proteins between membranes. Thereby, it regulates the membrane association of Ras and Rap GTPases (PMID: 36672247). In addition, research has shown that PDE6D is overexpressed in liver cancer and correlated with tumor stages, grading, and ERK activation (PMID: 30901922). The calculated molecular weight of PDE6D is 17 kDa.