验证数据展示
产品信息
18211-1-PBS targets PCDHAC2 in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
| 经测试应用 | WB, Indirect ELISA Application Description |
| 经测试反应性 | human, mouse, rat |
| 免疫原 |
CatNo: Ag12889 Product name: Recombinant human PCDHAC2 protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 42-406 aa of BC104776 Sequence: SQLRYSVPEEQAPGALVGNVARALGLELRRLGPGCLRINHLGAPSPRYLELDLTSGALFVNERIDREALCEQRPRCLLSLEVLAHNPVAVSAVEVEILDINDNSPRFPRPNYQLQVSESVAPGARFHIESAQDPDVGANSVQTYELSPSEHFELDLKPLQENSKVLELVLRKGLDREQAALHHLVLTAVDGGIPARSGTAQISVRVLDTNDNSPAFDQSTYRVQLREDSPPGTLVVKLNASDPDEGSNGELRYSLSSYTSDRERQLFSIDASTGEVRVIGGLDYEEASSYQIYVQATDRGPVPMAGHCKVLVDIVDVNDNAPEVVLTDLYSPVPENATPNTIVAVLSVNDQDSGPNRKVSLGLEA 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | protocadherin alpha subfamily C, 2 |
| 别名 | PCDH-alpha-C2, Protocadherin alpha-C2 |
| 计算分子量 | 884 aa, 96 kDa |
| 观测分子量 | 120 kDa |
| GenBank蛋白编号 | BC104776 |
| 基因名称 | PCDHAC2 |
| Gene ID (NCBI) | 56134 |
| RRID | AB_3741948 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | Q9Y5I4 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Protocadherins, which constitute the largest subgroup within the cadherin superfamily, are predominantly expressed in the nervous system and are probably involved in the regulation of neuronal recognition and connectivity (PMID: 17936607; 12231349; 17133224). The protocadherin subfamily can be further subdivided into three groups: the clustered protocadherins, comprising α-, β-, and γ-protocadherins; δ-protocadherins; and others, many of which are solitary (PMID: 17133224). PCDHAC2 is a subtype of α-protocadherins, mainly expressed by serotonergic neurons. PCDHAC2 is essential for the diffuse projection of serotonergic axons (PMID: 29162883).
