验证数据展示
产品信息
34123-1-PBS targets PCDH18 in IHC, Indirect ELISA applications and shows reactivity with human samples.
| 经测试应用 | IHC, Indirect ELISA Application Description |
| 经测试反应性 | human |
| 免疫原 |
CatNo: Ag41285 Product name: Recombinant human PCDH18 protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 750-900 aa of BC093815 Sequence: PSRQIHKGDITLVPTINGTLPIRSHHRSSPSSSPTLERGQMGSRQSHNSHQSLNSLVTISSNHVPENFSLELTHATPAVEQVSQLLSMLHQGQYQPRPSFRGNKYSRSYRYALQDMDKFSLKDSGRGDSEAGDSDYDLGRDSPIDRLLGEG 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | protocadherin 18 |
| 别名 | KIAA1562, PCDH68L, Protocadherin-18 |
| 计算分子量 | 1135 aa, 126 kDa |
| GenBank蛋白编号 | BC093815 |
| 基因名称 | PCDH18 |
| Gene ID (NCBI) | 54510 |
| RRID | AB_3743157 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity Purification |
| UNIPROT ID | Q9HCL0 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Protocadherin 18 (PCDH18) is a member of the non-clustered protocadherin subfamily within the cadherin superfamily. Encoded by the PCDH18 gene on chromosome 4q28, it contains six to seven extracellular cadherin repeats, a transmembrane domain, and a cytoplasmic tail. PCDH18 is expressed in brain, heart, kidney, lung, and trachea. It plays critical roles in cell-cell adhesion, neuronal migration, axon guidance, and synapse formation during development. Emerging evidence links PCDH18 mutations or dysregulation to neurodevelopmental disorders, including autism spectrum disorder and intellectual disability, as well as to certain cancers (PMID: 22450339; PMID: 29075151; PMID: 28588296).
