Nucleotides, the structural subunits of the nucleic acids, are also important extracellular signaling molecules. P2 receptors are a family of cell surface receptors that mediate a wide variety of physiologic effects in response to extracellular nucleotides. These receptors fall into two classes: P2X receptors, which are ligand-gated ion channels that mediate calcium and potassium fluxes in response to ATP, and P2Y receptors, which are G protein-coupled receptors (GPCRs). P2Y purinoceptor 11 (P2RY11) is a receptor for ATP and ADP coupled to G-proteins that activate both phosphatidylinositol-calcium and adenylyl cyclase second messenger systems. It is not activated by UTP or UDP (PMID: 9405388). Expression of P2RY11 has been detected in immune cells including dendritic cells, macrophages and non‐immune cells including cancer cells (PMID: 33463722). It is involved in immune regulation (PMID: 27246167). No murine P2ry11 has been identified.