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验证数据展示

  • WB analysis using 60293-1-Ig (same clone as 60293-1-PBS)

    WB analysis using 60293-1-Ig (same clone as 60293-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 60293-1-Ig (OPTN/Optineurin antibody) at dilution of 1:20000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 60293-1-PBS in a different storage buffer formulation.

  • IHC staining of human pancreas cancer using 60293-1-Ig (same clone as 60293-1-PBS)

    IHC staining of human pancreas cancer using 60293-1-Ig (same clone as 60293-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human pancreas cancer tissue slide using 60293-1-Ig (OPTN Antibody) at dilution of 1:200 (under 10x lens). This data was developed using the same antibody clone with 60293-1-PBS in a different storage buffer formulation.

  • IHC staining of human pancreas cancer using 60293-1-Ig (same clone as 60293-1-PBS)

    IHC staining of human pancreas cancer using 60293-1-Ig (same clone as 60293-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human pancreas cancer tissue slide using 60293-1-Ig (OPTN Antibody) at dilution of 1:200 (under 40x lens). This data was developed using the same antibody clone with 60293-1-PBS in a different storage buffer formulation.

  • WB analysis of HeLa using 60293-1-Ig (same clone as 60293-1-PBS)

    WB analysis of HeLa using 60293-1-Ig (same clone as 60293-1-PBS)

    WB result of OPTN/Optineurin antibody (60293-1-Ig; 1:4000; incubated at room temperature for 1.5 hours) with sh-Control and sh-OPTN/Optineurin transfected HeLa cells. This data was developed using the same antibody clone with 60293-1-PBS in a different storage buffer formulation.

  • IF Staining of MCF-7 using 60293-1-Ig (same clone as 60293-1-PBS)

    IF Staining of MCF-7 using 60293-1-Ig (same clone as 60293-1-PBS)

    Immunofluorescent analysis of (-20°C Methanol) fixed MCF-7 cells using OPTN antibody (60293-1-Ig, Clone: 6C1H4 ) at dilution of 1:800 and CoraLite®488-Conjugated Goat Anti-Mouse IgG(H+L) (SA00013-1). This data was developed using the same antibody clone with 60293-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO验证

OPTN/Optineurin Monoclonal antibody, PBS Only

OPTN/Optineurin Monoclonal Antibody for WB, IHC, IF/ICC, Indirect ELISA
Cat No. 60293-1-PBS

产品说明书

CloneNo. 6C1H4

宿主/亚型

Mouse / IgG1

种属反应性

human, pig

应用

WB, IHC, IF/ICC, Indirect ELISA

别名

Optineurin, OPTN, 6C1H4, ALS12, E3-14.7K-interacting protein

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

60293-1-PBS targets OPTN/Optineurin in WB, IHC, IF/ICC, Indirect ELISA applications and shows reactivity with human, pig samples.

经测试应用 WB, IHC, IF/ICC, Indirect ELISA Application Description
经测试反应性 human, pig
免疫原

CatNo: Ag1272

Product name: Recombinant human OPTN protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 233-577 aa of BC013876

Sequence: VSQLLLCLREGNQKVERLEVALKEAKERVSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKKLELQVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAVLKELSEKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAERAAREKIHEEKEQLALQLAVLLKENDAFEDGGRQSLMEMQSRHGARTSDSDQQAYLVQRGAEDRDWRQQRNIPIHSCPKCGEVLPDIDTLQIHVMDCII

种属同源性预测
宿主/亚型 Mouse / IgG1
抗体类别 Monoclonal
产品类型 Antibody
全称 optineurin
别名 Optineurin, OPTN, 6C1H4, ALS12, E3-14.7K-interacting protein
计算分子量 66 kDa
观测分子量 70-74 kDa
GenBank蛋白编号BC013876
基因名称 OPTN
Gene ID (NCBI) 10133
RRIDAB_2881408
偶联类型 Unconjugated
形式Liquid
纯化方式Protein G purification
UNIPROT IDQ96CV9
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

OPTN, also named as FIP2, GLC1E, HIP7, HYPL and NRP, plays a neuroprotective role in the eye and optic nerve. It is probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. OPTN may act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). OPTN may constitute a cellular target for adenovirus E3 14.7, an inhibitor of TNF-alpha functions, thereby affecting cell death. Defects in OPTN are a cause of susceptibility to normal pressure glaucoma (NPG). OPTN mutated in adult-onset primary open angle glaucoma. It supports the protective role of OPTN in the trabecular meshwork.

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