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验证数据展示

  • WB analysis using 86194-3-RR (same clone as 86194-3-PBS)

    WB analysis using 86194-3-RR (same clone as 86194-3-PBS)

    Human placenta tissue was subjected to SDS PAGE followed by western blot with 86194-3-RR (OLR1 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86194-3-PBS in a different storage buffer formulation.

  • WB analysis using 86194-3-RR (same clone as 86194-3-PBS)

    WB analysis using 86194-3-RR (same clone as 86194-3-PBS)

    bEnd.3 cells were subjected to SDS PAGE followed by western blot with 86194-3-RR (OLR1 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86194-3-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 86194-3-RR

    Affinity and Kinetic Characterization of 86194-3-RR

    Biolayer interferometry (BLl) kinetic assays of 86194-3-RR against Human OLR1/LOX1 were performed. The affinity constant is 1.92 nM.

OLR1/LOX1 Recombinant monoclonal antibody, PBS Only

OLR1/LOX1 Uni-rAb® Recombinant Antibody for WB, Indirect ELISA
Cat No. 86194-3-PBS

产品说明书

CloneNo. 250525A3

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse

应用

WB, Indirect ELISA

别名

OLR1, CLEC8A, C-type lectin domain family 8 member A, hLOX 1, hLOX1

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

86194-3-PBS targets OLR1/LOX1 in WB, Indirect ELISA applications and shows reactivity with human, mouse samples.

经测试应用 WB, Indirect ELISA Application Description
经测试反应性 human, mouse
免疫原

CatNo: Eg2911

Product name: Recombinant Human OLR1/LOX1 protein (rFc Tag)

Source: mammalian cells-derived, V37

Tag: C-rFc

Domain: 61-273 aa of NM_002543.3

Sequence: SQVSDLLTQEQANLTHQKKKLEGQISARQQAEEASQESENELKEMIETLARKLNEKSKEQMELHHQNLNLQETLKRVANCSAPCPQDWIWHGENCYLFSSGSFNWEKSQEKCLSLDAKLLKINSTADLDFIQQAISYSSFPFWMGLSRRNPSYPWLWEDGSPLMPHLFRVRGAVSQTYPSGTCAYIQRGAVYAENCILAAFSICQKKANLRAQ

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 oxidized low density lipoprotein (lectin-like) receptor 1
别名 OLR1, CLEC8A, C-type lectin domain family 8 member A, hLOX 1, hLOX1
计算分子量31 kDa
观测分子量 50-55 kDa
GenBank蛋白编号NM_002543.3
基因名称 OLR1
Gene ID (NCBI) 4973
RRIDAB_3744703
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purification
UNIPROT IDP78380-1
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

OLR1/LOX-1 acts as a receptor, in the form of a homodimer, that mediates the recognition, internalization, and degradation of oxidatively modified low density lipoprotein (oxLDL) (PMID: 9052782, 15695803). ORL1 is predominantly expressed in endothelial cells and vascular-rich organs such as the placenta, lung, liver, and brain (PMID: 9828121). OLR1 is a protein containing 273 amino acids with a calculated molecular mass of 31 kDa but an apparent molecular mass of 50 kDa, which may result from the glycosylation of four potential N-linked glycosylation sites located at the C-terminal domain (PMID: 9052782).

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