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Notoginsenoside R1

Notoginsenoside R1 (Sanchinoside R1) 属于皂苷类天然产物，是三七的主要活性单体。Notoginsenoside R1 具有心血管保护、神经保护、肝脏保护、抗肿瘤、免疫调节等活性。

CAS号

80418-24-2

分子式

C47H80O18

主要靶点

Apoptosis|ERK|Beta Amyloid

仅限科研使用

Cat No : CM06779

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Synonyms

Beta Amyloid|BetaAmyloid|bAmyloid|b Amyloid|Amyloid-β|anti-angiogenic|anti-apoptosis,cardioprotection|Apoptosis|anti-oxidation|anti-inflammatory|Abeta|ERK1|ERK2|inhibit|I/R|三七皂苷R1|β-amyloid peptide|βAmyloid|β Amyloid|Sanchinoside R 1|Sanchinoside R1|Sanchinoside R-1|saponin|Sanqi glucoside R 1|Sanqi glucoside R1|Sanqi glucoside R-1|Notoginsenoside R 1|Notoginsenoside R1|Notoginsenoside R-1|neuroprotection|Inhibitor

验证数据展示

  • CAS No.: 80418-24-2

    Notoginsenoside R1
    CAS#: 80418-24-2

产品信息

Notoginsenoside R1 (Sanchinoside R1) belongs to the saponin class of natural products, and is the main active monomer of Panax ginseng. Notoginsenoside R1 has cardiovascular, neuroprotective, hepatoprotective, antitumor and immunomodulatory activities.

CAS号 80418-24-2
分子式 C47H80O18
主要靶点 Apoptosis|ERK|Beta Amyloid
主要通路 神经科学|MAPK 信号通路|凋亡
分子量 933.13
纯度 100%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 Beta Amyloid|BetaAmyloid|bAmyloid|b Amyloid|Amyloid-β|anti-angiogenic|anti-apoptosis,cardioprotection|Apoptosis|anti-oxidation|anti-inflammatory|Abeta|ERK1|ERK2|inhibit|I/R|三七皂苷R1|β-amyloid peptide|βAmyloid|β Amyloid|Sanchinoside R 1|Sanchinoside R1|Sanchinoside R-1|saponin|Sanqi glucoside R 1|Sanqi glucoside R1|Sanqi glucoside R-1|Notoginsenoside R 1|Notoginsenoside R1|Notoginsenoside R-1|neuroprotection|Inhibitor

体内活性

方法：为研究对新生内膜增生的影响，将 Notoginsenoside R1 (10 mg/kg) 腹腔注射给 C57BL/6?J 小鼠，每天一次，持续三周。随后进行了小鼠股动脉损伤模型。 结果：Notoginsenoside R1 在体内减轻股动脉损伤后新生内膜的形成。Notoginsenoside R1 治疗通过抑制 VSMC 增殖来减少新生内膜的形成。[2]

体外活性

方法：人结直肠癌细胞 HCT-116 用 Notoginsenoside R1 (75-300 μM) 处理 48 h，使用 MTT assay 检测细胞活力。 结果：用 75-300 μM Notoginsenoside R1 处理后的 HCT-116 细胞活力与对照组没有显著差异。然而，与对照细胞相比，用 500 μM Notoginsenoside R1 处理 48 h 的细胞活力显著降低 (58±7.26%)。[1] 方法：人冠状动脉平滑肌细胞 hCASMC 用 Notoginsenoside R1 (10 μM) 处理 24 h，用 10% FBS 刺激 0-30 min，使用 Western Blot 检测靶点蛋白表达水平。 结果：Notoginsenoside R1 处理后 hCASMCs 中 Akt 磷酸化以时间和剂量依赖的方式快速降低，但未观察到对 ERK1/2 和 JNK 信号传导的影响。Notoginsenoside R1 引起 p38 MAPK 磷酸化的适度降低，但这没有达到显著性。[2]

溶解度

DMSO:25 mg/mL (26.79 mM); H2O:2.5 mg/mL (2.68 mM);

参考文献

1.Lee CY, et al. Inhibition of human colorectal cancer metastasis by notoginsenoside R1, an important compound from Panax notoginseng. Oncol Rep. 2017 Jan;37(1):399-407.
2.Fang H, et al. Notoginsenoside R1 inhibits vascular smooth muscle cell proliferation, migration and neointimal hyperplasia through PI3K/Akt signaling. Sci Rep. 2018 May 15;8(1):7595.

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