×
Use Able AI chat for product recommendations

验证数据展示

  • Neutralization experiment of NeutraKine® BMP-7 using 69011-1-Ig (same clone as 69011-1-PBS)

    Neutralization experiment of NeutraKine® BMP-7 using 69011-1-Ig (same clone as 69011-1-PBS)

    Recombinant human BMP-7 (Cat.NO. HZ-1229) induces alkaline phosphatase production in the ATDC-5 cell line (using pNPP as chromogenic substrate for detection) in a dose dependent manner (blue curve, bottom X-left Y). The activity of human BMP-7 (200 ng/mL HZ-1229) is neutralized by mouse anti-human BMP-7 antibody 69011-1-Ig at serial dose (red curve, refer to top X-right Y). The ND50 is typically 1-2 μg/mL. This data was developed using the same antibody clone with 69011-1-PBS in a different storage buffer formulation.

  • FC experiment of HEK-293 using 69011-1-Ig (same clone as 69011-1-PBS)

    FC experiment of HEK-293 using 69011-1-Ig (same clone as 69011-1-PBS)

    1X10^6 HEK-293 cells were intracellularly stained with 0.4 ug Anti-Human NeutraKine® BMP-7 (69011-1-Ig, Clone:3E9G7) and CoraLite®488-Conjugated AffiniPure Goat Anti-Mouse IgG(H+L) at dilution 1:1000 (red), or 0.4 ug Control Antibody. Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer. This data was developed using the same antibody clone with 69011-1-PBS in a different storage buffer formulation.

NeutraKine® BMP-7 Monoclonal antibody, PBS Only

NeutraKine® BMP-7 Monoclonal Antibody for FC (Intra), Neutralization, Indirect ELISA
Cat No. 69011-1-PBS

产品说明书

CloneNo. 3E9G7

宿主/亚型

Mouse / IgG1

种属反应性

human, mouse

应用

FC (Intra), Neutralization, Indirect ELISA

别名

BMP7, 3E9G7, BMP 7, BMP-7, Bone morphogenetic protein 7

缓冲液配方:  Liquid
Lyophilized
Liquid
偶联物:  Unconjugated
规格价格库存

点击咨询售前客服

点击咨询售后客服

产品信息

69011-1-PBS targets NeutraKine® BMP-7 in FC (Intra), Neutralization, Indirect ELISA applications and shows reactivity with human, mouse samples.

经测试应用 FC (Intra), Neutralization, Indirect ELISA Application Description
经测试反应性 human, mouse
免疫原

CatNo:

Product name: HumanKine® recombinant human BMP-7 protein

Source: -derived,

Tag:

Domain: of

Sequence:

种属同源性预测
宿主/亚型 Mouse / IgG1
抗体类别 Monoclonal
产品类型 Antibody
全称 bone morphogenetic protein 7
别名 BMP7, 3E9G7, BMP 7, BMP-7, Bone morphogenetic protein 7
基因名称 BMP7
Gene ID (NCBI) 655
偶联类型 Unconjugated
纯化方式Protein G purification
UNIPROT IDP18075
储存缓冲液 PBS only, pH 7.3.
储存Store at -80°C.

背景介绍

The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site.

BMP7, also known as osteogenic protein-1 or OP-1, plays a key role in the transformation of mesenchymal cells into bone and cartilage. BMP7 may be involved in bone homeostasis (PMID: 15621726). It is expressed in the brain, kidneys and bladder. BMP7 is also present in cancers, including breast, prostate, and colon cancers, in which it is implicated in regulating cancer cell proliferation (PMID: 16419056, PMID: 15531927). Overexpression of BMP7 mRNA in colorectal cancer patients was significantly associated with poor prognosis and low overall survival (PMID: 18259822). Recent studies suggest that high-expression level of BMP7 serves as a biomarker for poor prognosis for HCC (PMID: 23179403).

This antibody can be used to neutralize the bioactivity of BMP-7.

||
New chat

Able™

正在加载，请稍候...