验证数据展示
| Neutralization |
产品信息
69011-1-Ig targets NeutraKine® BMP-7 in FC (Intra), Neutralization, ELISA, Cell treatment applications and shows reactivity with human, mouse samples.
| 经测试应用 | FC (Intra), Neutralization, ELISA Application Description |
| 文献引用应用 | Cell treatment |
| 经测试反应性 | human, mouse |
| 文献引用反应性 | rat |
| 免疫原 |
Product name: HumanKine® recombinant human BMP-7 protein Source: -derived, Tag: Sequence: 种属同源性预测 |
| 宿主/亚型 | Mouse / IgG1 |
| 抗体类别 | Monoclonal |
| 产品类型 | Antibody |
| 全称 | bone morphogenetic protein 7 |
| 别名 | BMP7, 3E9G7, BMP 7, BMP-7, Bone morphogenetic protein 7 |
| 基因名称 | BMP7 |
| Gene ID (NCBI) | 655 |
| RRID | AB_2882929 |
| 偶联类型 | Unconjugated |
| 形式 | Lyophilized Powder |
| 纯化方式 | Protein G purification |
| UNIPROT ID | P18075 |
| 储存缓冲液 | Sterile PBS, pH 7.4. |
| 内毒素 | <0.1 EU/μg |
| 复溶 | This product was lyophilized from a 0.2 μm filtered solution in PBS. Reconstitute at 1.0 mg/mL in sterile H2O before use. |
| 稳定性与储存 | Lyophilized antibodies are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products. |
背景介绍
The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site.
BMP7, also known as osteogenic protein-1 or OP-1, plays a key role in the transformation of mesenchymal cells into bone and cartilage. BMP7 may be involved in bone homeostasis (PMID: 15621726). It is expressed in the brain, kidneys and bladder. BMP7 is also present in cancers, including breast, prostate, and colon cancers, in which it is implicated in regulating cancer cell proliferation (PMID: 16419056, PMID: 15531927). Overexpression of BMP7 mRNA in colorectal cancer patients was significantly associated with poor prognosis and low overall survival (PMID: 18259822). Recent studies suggest that high-expression level of BMP7 serves as a biomarker for poor prognosis for HCC (PMID: 23179403).
This antibody can be used to neutralize the bioactivity of BMP-7.
实验方案
| Product Specific Protocols | |
|---|---|
| FC protocol for NeutraKine® BMP-7 antibody 69011-1-Ig | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
