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验证数据展示

  • WB analysis using 85994-1-RR (same clone as 85994-1-PBS)

    WB analysis using 85994-1-RR (same clone as 85994-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 85994-1-RR (NPTXR antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85994-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse brain using 85994-1-RR (same clone as 85994-1-PBS)

    IHC staining of mouse brain using 85994-1-RR (same clone as 85994-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 85994-1-RR (NPTXR antibody) at dilution of 1:500 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 85994-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse brain using 85994-1-RR (same clone as 85994-1-PBS)

    IHC staining of mouse brain using 85994-1-RR (same clone as 85994-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 85994-1-RR (NPTXR antibody) at dilution of 1:500 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 85994-1-PBS in a different storage buffer formulation.

  • IF Staining of mouse brain using 85994-1-RR (same clone as 85994-1-PBS)

    IF Staining of mouse brain using 85994-1-RR (same clone as 85994-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed paraffin-embedded mouse brain tissue using NPTXR antibody (85994-1-RR, Clone: 250488B3 ) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 85994-1-PBS in a different storage buffer formulation.

  • IF Staining of mouse brain using 85994-1-RR (same clone as 85994-1-PBS)

    IF Staining of mouse brain using 85994-1-RR (same clone as 85994-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed paraffin-embedded mouse brain tissue using NPTXR antibody (85994-1-RR, Clone: 250488B3 ) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 85994-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 85994-1-RR

    Affinity and Kinetic Characterization of 85994-1-RR

    Biolayer interferometry (BLl) kinetic assays of 85994-1-RR against Human NPTXR were performed. The affinity constant is 0.161 nM.

NPTXR Recombinant monoclonal antibody, PBS Only

NPTXR Uni-rAb® Recombinant Antibody for WB, IHC, IF-P, Indirect ELISA
Cat No. 85994-1-PBS

产品说明书

CloneNo. 250488B3

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse

应用

WB, IHC, IF-P, Indirect ELISA

别名

Neuronal pentraxin receptor

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

85994-1-PBS targets NPTXR in WB, IHC, IF-P, Indirect ELISA applications and shows reactivity with human, mouse samples.

经测试应用 WB, IHC, IF-P, Indirect ELISA Application Description
经测试反应性 human, mouse
免疫原

CatNo: Eg3109

Product name: Recombinant Human NPTXR protein (rFc Tag)

Source: mammalian cells-derived, V37

Tag: C-rFc

Domain: 24-500 aa of NM_014293.3

Sequence: ASVPLAASPARALPGGADNASVASGAAASPGPQRSLSALHGAGGSAGPPALPGAPAASAHPLPPGPLFSRFLCTPLAAACPSGAQQGDAAGAAPGEREELLLLQSTAEQLRQTALQQEARIRADQDTIRELTGKLGRCESGLPRGLQGAGPRRDTMADGPWDSPALILELEDAVRALRDRIDRLEQELPARVNLSAAPAPVSAVPTGLHSKMDQLEGQLLAQVLALEKERVALSHSSRRQRQEVEKELDVLQGRVAELEHGSSAYSPPDAFKISIPIRNNYMYARVRKALPELYAFTACMWLRSRSSGTGQGTPFSYSVPGQANEIVLLEAGHEPMELLINDKVAQLPLSLKDNGWHHICIAWTTRDGLWSAYQDGELQGSGENLAAWHPIKPHGILILGQEQDTLGGRFDATQAFVGDIAQFNLWDHALTPAQVLGIANCTAPLLGNVLPWEDKLVEAFGGATKAAFDVCKGRAKA

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 neuronal pentraxin receptor
别名 Neuronal pentraxin receptor
计算分子量53 kDa
观测分子量35-65 kDa
GenBank蛋白编号NM_014293.3
基因名称 NPTXR
Gene ID (NCBI) 23467
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purification
UNIPROT IDO95502
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

NPTXR (Neuronal Pentraxin Receptor) is a type II transmembrane glycoprotein primarily expressed in the cerebellum and hippocampus. It mediates synaptic plasticity by clustering AMPA-type glutamate receptors at excitatory synapses and promoting synaptogenesis. NPTXR can be proteolytically cleaved to release a soluble form. Its dysregulation is implicated in Alzheimer's disease and small-cell lung cancer.(PMID: 9261167; 18367087; 19368810; 16115696)

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