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验证数据展示

  • WB analysis using 10889-1-AP (same clone as 10889-1-PBS)

    WB analysis using 10889-1-AP (same clone as 10889-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 10889-1-AP (NPTX2 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 10889-1-PBS in a different storage buffer formulation.

  • IP experiment of mouse brain using 10889-1-AP (same clone as 10889-1-PBS)

    IP experiment of mouse brain using 10889-1-AP (same clone as 10889-1-PBS)

    IP result of anti-NPTX2 (IP:10889-1-AP, 4ug; Detection:10889-1-AP 1:600) with mouse brain tissue lysate 4000ug. This data was developed using the same antibody clone with 10889-1-PBS in a different storage buffer formulation.

  • IHC staining of human brain using 10889-1-AP (same clone as 10889-1-PBS)

    IHC staining of human brain using 10889-1-AP (same clone as 10889-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human brain tissue slide using 10889-1-AP (NPTX2 Antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 10889-1-PBS in a different storage buffer formulation.

  • IHC staining of human brain using 10889-1-AP (same clone as 10889-1-PBS)

    IHC staining of human brain using 10889-1-AP (same clone as 10889-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human brain tissue slide using 10889-1-AP (NPTX2 Antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 10889-1-PBS in a different storage buffer formulation.

  • IF Staining of SH-SY5Y using 10889-1-AP (same clone as 10889-1-PBS)

    IF Staining of SH-SY5Y using 10889-1-AP (same clone as 10889-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed SH-SY5Y cells using NPTX2 antibody (10889-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L) (SA00013-2), CL594-phalloidin (red). This data was developed using the same antibody clone with 10889-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO验证

NPTX2 Polyclonal antibody, PBS Only

NPTX2 Polyclonal Antibody for WB, IHC, IF/ICC, IP, ELISA
Cat No. 10889-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, IF/ICC, IP, ELISA

别名

Neuronal pentraxin II, Neuronal pentraxin-2, NP2, NP-II

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

10889-1-PBS targets NPTX2 in WB, IHC, IF/ICC, IP, ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, IF/ICC, IP, ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag1326

Product name: Recombinant human NPTX2 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-350 aa of BC009924

Sequence: MLALLAASVALAVAAGAQDSPAPGSRFVCTALPPEAVHAGCPLPAMPMQGGAQSPEEELRAAVLQLRETVVQQKETLGAQREAIRELTGKLARCEGLAGGKARGAGATGKDTMGDLPRDPGHVVEQLSRSLQTLKDRLESLEHQLRANVSNAGLPGDFREVLQQRLGELERQLLRKVAELEDEKSLLHNETSAHRQKTESTLNALLQRVTELERGNSAFKSPDAFKVSLPLRTNYLYGKIKKTLPELYAFTICLWLRSSASPGIGTPFSYAVPGQANEIVLIEWGNNPIELLINDKVAQLPLFVSDGKWHHICVTWTTRDGMWEAFQDGEKLGTGENLAPWHPIKPGGVL

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 neuronal pentraxin II
别名 Neuronal pentraxin II, Neuronal pentraxin-2, NP2, NP-II
计算分子量 47 kDa
观测分子量 47-50 kDa
GenBank蛋白编号BC009924
基因名称 NPTX2
Gene ID (NCBI) 4885
RRIDAB_2153875
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDP47972
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Neuronal pentraxins constitute a family of proteins that are homologous to C-reactive protein (CRP) and serum amyloid P component (SAP), including NPTX1, NPTX2, and the neuronal pentraxin receptor (NPTXR). NPTX2, also known as NARP (neuronal activity-regulated pentaxin), is a secreted protein involved in excitatory synapse formation. It also plays a role in the clustering of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors at established synapses, resulting in non-apoptotic cell death of dopaminergic nerve cells. NPTX2 is highly up-regulated in Parkinson's disease (PD), suggesting it may be involved in the pathology of PD. (PMID: 12895424; 17987278; 10748068)

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