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NPS2390

CAS号

226878-01-9

分子式

C19H21N3O

主要靶点

GluR

仅限科研使用

Cat No : CM05097

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Synonyms

Inhibitor|mGluR|Metabotropic glutamate receptors|NPS 2390|NPS2390|NPS-2390|inhibit|CaSR|Calcium-sensing receptor

验证数据展示

  • CAS No.: 226878-01-9

    NPS2390
    CAS#: 226878-01-9

产品信息

CAS号 226878-01-9
分子式 C19H21N3O
主要靶点 GluR
主要通路 神经科学
分子量 307.39
纯度 97.13%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 Inhibitor|mGluR|Metabotropic glutamate receptors|NPS 2390|NPS2390|NPS-2390|inhibit|CaSR|Calcium-sensing receptor

靶点活性

mGluR5:82 nM|mGluR1:5.2nM

体外活性

Treatment of NPS2390 was conducive to inhibit the proliferation and reverse phenotypic modulation of PASMCs by regulating autophagy levels.

溶解度

DMSO:3.07 mg/mL (10 mM)

参考文献

1.Peng X , Wei C , Li H Z , et al. NPS2390, a Selective Calcium-sensing Receptor Antagonist Controls the Phenotypic Modulation of Hypoxic Human Pulmonary Arterial Smooth Muscle Cells by Regulating Autophagy[J]. Journal of Translational Internal Medicine, 2019, 7(2):59-68.

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