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验证数据展示

  • WB analysis using 33280-1-AP (same clone as 33280-1-PBS)

    WB analysis using 33280-1-AP (same clone as 33280-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 33280-1-AP (NOTCH4 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 33280-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse lung using 33280-1-AP (same clone as 33280-1-PBS)

    IHC staining of mouse lung using 33280-1-AP (same clone as 33280-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse lung tissue slide using 33280-1-AP (NOTCH4 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 33280-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse heart using 33280-1-AP (same clone as 33280-1-PBS)

    IHC staining of mouse heart using 33280-1-AP (same clone as 33280-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse heart tissue slide using 33280-1-AP (NOTCH4 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 33280-1-PBS in a different storage buffer formulation.

NOTCH4 Polyclonal antibody, PBS Only

NOTCH4 Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 33280-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse

应用

WB, IHC, Indirect ELISA

别名

hNotch4, INT3, Notch 4, Notch 4 extracellular truncation, Notch 4 intracellular domain

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

33280-1-PBS targets NOTCH4 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, mouse
免疫原

CatNo: Ag36738

Product name: Recombinant human NOTCH4 protein

Source: e coli.-derived, PET28a

Tag: 6*His

Domain: 309-648 aa of BC140782

Sequence: DCSEDVDECETQGPPHCRNGGTCQNSAGSFHCVCVSGWGGTSCEENLDDCIAATCAPGSTCIDRVGSFSCLCPPGRTGLLCHLEDMCLSQPCHGDAQCSTNPLTGSTLCLCQPGYSGPTCHQDLDECLMAQQGPSPCEHGGSCLNTPGSFNCLCPPGYTGSRCEADHNECLSQPCHPGSTCLDLLATFHCLCPPGLEGQLCEVETNECASAPCLNHADCHDLLNGFQCICLPGFSGTRCEEDIDECRSSPCANGGQCQDQPGAFHCKCLPGFEGPRCQTEVDECLSDPCPVGASCLDLPGAFFCLCPSGFTGQLCEVPLCAPNLCQPKQICKDQKDKANC

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 Notch homolog 4 (Drosophila)
别名 hNotch4, INT3, Notch 4, Notch 4 extracellular truncation, Notch 4 intracellular domain
计算分子量 2003 aa, 210 kDa
观测分子量210 kDa
GenBank蛋白编号BC140782
基因名称 NOTCH4
Gene ID (NCBI) 4855
RRIDAB_3742925
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity Purification
UNIPROT IDQ99466
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Neurogenic locus notch homolog protein 4 (NOTCH4) is a receptor involved in the Notch signaling pathway, which is synthesized as a precursor that undergoes proteolytic cleavage to form an active receptor. NOTCH4 interacts with various ligands, leading to the release of the Notch intracellular domain (NICD), which translocates to the nucleus and regulates gene expression (PMID: 28794168; 19379690; 17148788). NOTCH4 is involved in various biological processes, including embryonic development, immune cell differentiation, and tumorigenesis (PMID: 24667410; 34925319).

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