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验证数据展示

  • WB analysis of HEK-293 using 18424-1-AP (same clone as 18424-1-PBS)

    WB analysis of HEK-293 using 18424-1-AP (same clone as 18424-1-PBS)

    WB result of NOL7 antibody (18424-1-AP; 1:4000; incubated at room temperature for 1.5 hours) with sh-Control and sh-NOL7 transfected HEK-293 cells. This data was developed using the same antibody clone with 18424-1-PBS in a different storage buffer formulation.

  • WB analysis using 18424-1-AP (same clone as 18424-1-PBS)

    WB analysis using 18424-1-AP (same clone as 18424-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 18424-1-AP (NOL7 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 18424-1-PBS in a different storage buffer formulation.

  • IF Staining of U2OS using 18424-1-AP (same clone as 18424-1-PBS)

    IF Staining of U2OS using 18424-1-AP (same clone as 18424-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed U2OS cells using NOL7 antibody (18424-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2), CL594-Phalloidin (red). This data was developed using the same antibody clone with 18424-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO Validated

NOL7 Polyclonal antibody, PBS Only

NOL7 Polyclonal Antibody for WB, IF/ICC, Indirect ELISA
Cat No. 18424-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IF/ICC, Indirect ELISA

别名

C6orf90, NOP27, Nucleolar protein 7, nucleolar protein 7, 27kDa, Nucleolar protein of 27 kDa

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

18424-1-PBS targets NOL7 in WB, IF/ICC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IF/ICC, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag13272

Product name: Recombinant human NOL7 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-257 aa of BC023517

Sequence: MVQLRPRASRAPASAEAMVDEGQLASEEEEAEHGLLLGQPSSGAAAEPLEEDEEGDDEFDDEAPEELTFASAQAEAREEERRVRETVRRDKTLLKEKRKRREELFIEQKKRKLLPDTILEKLTTASQTNIKKSPGKVKEVNLQKKNEDCEKGNDSKKVKVQKVQSVSQNKSYLAVRLKDQDLRDSRQQAAQAFIHNSLYGPGTNRTTVNKFLSLANKRLPVKRAAVQFLNNAWGIQKKQNAKRFKRRWMVRKMKTKK

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 nucleolar protein 7, 27kDa
别名 C6orf90, NOP27, Nucleolar protein 7, nucleolar protein 7, 27kDa, Nucleolar protein of 27 kDa
计算分子量 257 aa, 29 kDa
观测分子量38 kDa
GenBank蛋白编号BC023517
基因名称 NOL7
Gene ID (NCBI) 51406
RRIDAB_3741952
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ9UMY1
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

NOL7 (nucleolar protein 7) is localized in both the nucleolus and nucleoplasm, with its nucleolar localization being RNA-dependent. Its function in the nucleolus is likely related to maintaining nucleolar structure and cell growth, while its role in the nucleoplasm may be associated with anti-angiogenic effects. Additionally, NOL7 is involved in the accumulation of early pre-rRNA and the processing of pre-18S rRNA, which are crucial for maintaining nucleolar function and cell growth. The expression of NOL7 is regulated by various transcription factors, including c-myc and RXRα. In cervical cancer, NOL7 transcription is also positively regulated by the RB tumor suppressor gene. The NOL7 gene encodes three distinct splice variants, each with different intracellular localizations that may affect their functions.

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