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Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

验证数据展示

  • WB analysis using 85973-3-RR (same clone as 85973-3-PBS)

    WB analysis using 85973-3-RR (same clone as 85973-3-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 85973-3-RR (NMDAR1 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85973-3-PBS in a different storage buffer formulation.

  • IP experiment of mouse brain using 85973-3-RR (same clone as 85973-3-PBS)

    IP experiment of mouse brain using 85973-3-RR (same clone as 85973-3-PBS)

    IP result of anti-NMDAR1/GRIN1 (IP:85973-3-RR, 4ug; Detection:85973-3-RR 1:1000) with mouse brain tissue lysate 1720 ug. This data was developed using the same antibody clone with 85973-3-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 85973-3-RR

    Affinity and Kinetic Characterization of 85973-3-RR

    Biolayer interferometry (BLl) kinetic assays of 85973-3-RR against Human NMDAR1/GRIN1 were performed. The affinity constant is below 1 pM.

NMDAR1/GRIN1 Recombinant antibody, PBS Only

NMDAR1/GRIN1 Uni-rAbTM Recombinant Antibody for WB, IP, Indirect ELISA
Cat No. 85973-3-PBS

产品说明书

CloneNo. 250535B1

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IP, Indirect ELISA

别名

GRIN1, NMDAR1, GluN1, Glutamate receptor ionotropic, NMDA 1, NMDAR 1

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

85973-3-PBS targets NMDAR1/GRIN1 in WB, IP, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IP, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原 NMDAR1/GRIN1 fusion protein Ag26093 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 glutamate receptor, ionotropic, N-methyl D-aspartate 1
别名 GRIN1, NMDAR1, GluN1, Glutamate receptor ionotropic, NMDA 1, NMDAR 1
计算分子量 105 kDa
观测分子量116-120 kDa
GenBank蛋白编号NM_000832
基因名称 NMDAR1
Gene ID (NCBI) 2902
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDQ05586
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

GRIN1 encodes subunit 1 of the N-methyl-D-aspartate (NMDA) receptor, which is a heteromeric glutamate-gated calcium ion channel essential for synaptic function in the brain (PMID: 25864721, PMID: 25864721). NMDARs play important roles in normal brain development and function, such as synaptic plasticity, neural development, learning and memory (PMID: 20716669). NMDAR dysfunction has been associated with several neurological disorders including Parkinson, Alzheimer and Huntington diseases. Disrupted motor learning and long-term synaptic plasticity in mice lacking NMDAR1 in the striatum (PMID: 17015831).