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验证数据展示

  • WB analysis of HEK-293 using 33052-1-AP (same clone as 33052-1-PBS)

    WB analysis of HEK-293 using 33052-1-AP (same clone as 33052-1-PBS)

    WB result of NKX2-4 antibody (33052-1-AP; 1:1200; incubated at room temperature for 1.5 hours) with sh-Control and sh-NKX2-4 transfected HEK-293 cells. This data was developed using the same antibody clone with 33052-1-PBS in a different storage buffer formulation.

  • WB analysis using 33052-1-AP (same clone as 33052-1-PBS)

    WB analysis using 33052-1-AP (same clone as 33052-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 33052-1-AP (NKX2-4 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 33052-1-PBS in a different storage buffer formulation.

  • IF Staining of HEK-293 using 33052-1-AP (same clone as 33052-1-PBS)

    IF Staining of HEK-293 using 33052-1-AP (same clone as 33052-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed HEK-293 cells using NKX2-4 antibody (33052-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2), CL594-phalloidin (red). This data was developed using the same antibody clone with 33052-1-PBS in a different storage buffer formulation.

NKX2-4 Polyclonal antibody, PBS Only

NKX2-4 Polyclonal Antibody for WB, IF/ICC, Indirect ELISA
Cat No. 33052-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IF/ICC, Indirect ELISA

别名

Homeobox protein NK-2 homolog D, Homeobox protein Nkx-2.4, NKX2D

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

33052-1-PBS targets NKX2-4 in WB, IF/ICC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IF/ICC, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag37291

Product name: Recombinant human NKX2-4 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 288-354 aa of NM_033176

Sequence: QNGASTPTPGQAGPQPPAPTPAPELEELSPSPPALHGPGGGLAALDAAAGEYSGGVLGANLLYGRTW

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 NK2 homeobox 4
别名 Homeobox protein NK-2 homolog D, Homeobox protein Nkx-2.4, NKX2D
计算分子量36kDa
观测分子量38-41 kDa
GenBank蛋白编号NM_033176
基因名称 NKX2-4
Gene ID (NCBI) 644524
RRIDAB_3742839
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity Purification
UNIPROT IDQ9H2Z4
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

The NKX2-4 protein (full name: NK2 homeobox 4) belongs to the NK-2 type homeobox transcription factor family. Its main function is to act as a potential transcription factor, binding specifically to DNA sequences via its homeodomain and participating in the regulation of cell differentiation and the development of multicellular organisms. Studies have shown that this protein is active in the nucleus, and its aberrant expression may contribute to the development of acute myeloid leukemia by interfering with the normal differentiation of megakaryocytes and erythrocytes. Additionally, it can regulate the expression of genes such as TERT through allele-specific binding, thereby influencing tumor susceptibility in melanoma.

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