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验证数据展示

  • WB analysis using 11532-1-AP (same clone as 11532-1-PBS)

    WB analysis using 11532-1-AP (same clone as 11532-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 11532-1-AP (NKG7 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 11532-1-PBS in a different storage buffer formulation.

  • IP experiment of NK-92 using 11532-1-AP (same clone as 11532-1-PBS)

    IP experiment of NK-92 using 11532-1-AP (same clone as 11532-1-PBS)

    IP result of anti-NKG7 (IP:11532-1-AP, 4ug; Detection:11532-1-AP 1:1000) with NK-92 cells lysate 1120 ug. This data was developed using the same antibody clone with 11532-1-PBS in a different storage buffer formulation.

  • IHC staining of human colon cancer using 11532-1-AP (same clone as 11532-1-PBS)

    IHC staining of human colon cancer using 11532-1-AP (same clone as 11532-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using 11532-1-AP (NKG7 antibody) at dilution of 1:400 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 11532-1-PBS in a different storage buffer formulation.

NKG7 Polyclonal antibody, PBS Only

NKG7 Polyclonal Antibody for WB, IHC, IP, Indirect ELISA
Cat No. 11532-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IHC, IP, Indirect ELISA

别名

G CSF induced gene 1 protein, G-CSF-induced gene 1 protein, GIG 1 protein, GIG1, GIG-1 protein

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

11532-1-PBS targets NKG7 in WB, IHC, IP, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IHC, IP, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag2117

Product name: Recombinant human NKG7 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-165 aa of BC015759

Sequence: MELCRSLALLGGSLGLMFCLIALSTDFWFEAVGPTHSAHSGLWPTGHGDIISGYIHVTQTFSIMAVLWALVSVSFLVLSCFPSLFPPGHGPLVSTTAAFAAAISMVVAMAVYTSERWDQPPHPQIQTFFSWSFYLGWVSAILLLCTGALSLGAHCGGPRPGYETL

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 natural killer cell group 7 sequence
别名 G CSF induced gene 1 protein, G-CSF-induced gene 1 protein, GIG 1 protein, GIG1, GIG-1 protein
计算分子量 165 aa, 18 kDa
观测分子量18 kDa
GenBank蛋白编号BC015759
基因名称 NKG7
Gene ID (NCBI) 4818
RRIDAB_3741818
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ16617
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Natural killer cell granule protein 7 (NKG7) regulates lymphocyte granule exocytosis and downstream inflammation in a broad range of diseases. NKG7 expressed by CD4+ and CD8+ T cells were key in promoting inflammation during visceral leishmaniasis and malaria-two important parasitic diseases. It is expressed by natural killer cells and is critical for controlling cancer initiation, growth, and metastasis (PMID: 32839608; 8458737). In brief, NKG7 is a necessary T-cell intrinsic factor for the cytotoxic function of CD8+ T cells and established NKG7 as a new therapeutic target for cancer immunotherapy (PMID: 34911739).

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