验证数据展示
产品信息
33450-1-PBS targets NEPRO in WB, Indirect ELISA applications and shows reactivity with human samples.
| 经测试应用 | WB, Indirect ELISA Application Description |
| 经测试反应性 | human |
| 免疫原 |
CatNo: Ag38276 Product name: Recombinant human C3orf17 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 1-168 aa of NM_015412.3 Sequence: MMAAVPPGLEPWNRVRIPKAGNRSAVTVQNPGAALDLCIAAVIKECHLVILSLKSQTLDAETDVLCAVLYSNHNRMGRHKPHLALKQVEQCLKRLKNMNLEGSIQDLFELFSSNENQPLTTKVCVVPSQPVVELVLMKVLGACKLLLRLLDCCCKTFLLTVKHLGLQE 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | chromosome 3 open reading frame 17 |
| 别名 | C3orf17, Nucleolus and neural progenitor protein |
| 计算分子量 | 65kDa，567aa |
| 观测分子量 | 58 kDa |
| GenBank蛋白编号 | NM_015412.3 |
| 基因名称 | C3orf17 |
| Gene ID (NCBI) | 25871 |
| RRID | AB_3742976 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity Purification |
| UNIPROT ID | Q6NW34 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
The NEPRO protein (full name: Nucleolus and Neural Progenitor Protein) belongs to the NEPRO family and is primarily localized in the nucleolus. Its core function is to serve as a key downstream factor of the Notch signaling pathway during cerebral cortex development, where it maintains the stemness of neural progenitor cells by inhibiting their differentiation into neurons, thereby ensuring normal development of the nervous system. Additionally, this protein also plays an indispensable role during pre-implantation embryonic development in mice (PMID: 26178919).
