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Recombinant Mouse Nectin-2/CD112 protein (rFc Tag)

种属

Mouse

纯度

>90 %, SDS-PAGE

标签

rFc Tag

生物活性

未测试

Cat no : Eg2019

Print datasheet

Synonyms

CD112, Herpes virus entry mediator B, HveB, mHveB, Mph

验证数据展示

  • Purity of Recombinant Mouse Nectin-2 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Mouse Nectin-2 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 Not tested
来源 HEK293-derived Mouse Nectin-2 protein Gln32-Gly351 (Accession# P32507-1) with a rabbit IgG Fc tag at the C-terminus.
基因ID 19294
蛋白编号 P32507-1
预测分子量 57.8 kDa
SDS-PAGE 60-75 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

Nectin 2, also named as PVRL2, CD112, HVEB, PRR2 and PVRR2, is an adhesion molecule widely expressed in cell lines of different lineages, including hematopoietic, neuronal, endothelial and epithelial cells. CD112 belongs to a new family of immunoglobulin-like molecules that includes four members (CD111, CD112, PRR3 and CD155) sharing an ectodomain made of three Ig domains, of V and C types. CD112 is expressed in the myelo-monocytic and megakaryocytic hematopoietic lineages and the function in hematopoiesis is currently unknown. CD112 is an intercellular homophilic adhesion. CD112 localizes specifically at adherents junctions via its cytoplasmic interaction with the scaffold F-actin binding protein afadin. Disruption of the murine CD112 gene leads to infertility of male mice with morphologically aberrant spermatozoa. CD112 mediates entry of some alphaherpesvirus mutants (also named HveB) via its V domain. CD112 is involved in cell to cell spreading of viruses.

参考文献:

1. Kiyohito Mizutani, Yoshimi Takai. (2022) Mol Cell Biochem. Jan;477(1):167-180.
2. YeonSung Son, et al. (2016) PLoS One. Sep 27;11(9):e0163301.
3. Elisabeth Devilard, et al. (2013) PLoS One. Oct 7;8(10):e77424.
4. W M Martinez, P G Spear. (2001) J Virol. Nov;75(22):11185-95.
5. M S Warner, R J Geraghty. (1998) Virology. Jun 20;246(1):179-89.