Recombinant Mouse IGSF8/CD316 protein (rFc Tag)
种属
Mouse
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Mouse IGSF8 protein Arg26-Thr577 (Accession# Q8R366) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 140559 |
| 蛋白编号 | Q8R366 |
| 预测分子量 | 84.3 kDa |
| SDS-PAGE | 84-115 kDa , reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
IGSF8 (CD316/EWI‑2) is a type I transmembrane glycoprotein of immunoglobulin superfamily, interacting tightly with tetraspanins CD9 and CD81 to modulate membrane trafficking and cell adhesion. Widely expressed on immune and neuronal cells, it functions as a novel innate immune checkpoint: overexpressed in diverse malignancies, it binds NK‑cell KIR3DL2 to block NK‑mediated tumor clearance. Preclinical and early clinical data validate it as a promising immunotherapy target; blocking anti‑IGSF8 mAbs boost antitumor immunity alone or combined with anti‑PD1 regimens.
参考文献:
1. Li, Yulong et al. Cell vol. 187,11 (2024): 2703-2716.e23.
