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Monalizumab

CAS号

1228763-95-8

分子式

主要靶点

IFNAR|Chk

仅限科研使用

Cat No : CM13910

Print datasheet

Synonyms

Checkpoint Kinase (Chk)|IFNAR|莫那利珠单抗

验证数据展示

  • CAS No.: 1228763-95-8

    Monalizumab
    CAS#: 1228763-95-8

产品信息

CAS号 1228763-95-8
分子式
主要靶点 IFNAR|Chk
主要通路 免疫与炎症|细胞周期
分子量 147 kDa (average)
纯度 > 95%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 store at low temperature | store at -80°C | Shipping with blue ice.
别名 Checkpoint Kinase (Chk)|IFNAR|莫那利珠单抗

体内活性

Mice were intravenously injected with 200 μg of monalizumab, with an interval of 3-4 days, followed by intraperitoneal injection of 200 μg of RMP1-14. The results showed that monalizumab and RMP1-14 have synergistic effects in preclinical mouse tumor models[1].

体外活性

NK cells were incubated with monalizumab (1μg/mL) at 4°C for 30 minutes, followed by detection of total surface NKG2A using anti-human IgG4 (Fc)-PE. The results showed that monalizumab enhances the anti-tumor activity of human NK cells[1].

参考文献

1.Thorbald van Hall, et al. Monalizumab: inhibiting the novel immune checkpoint NKG2A. J Immunother Cancer. 2019 Oct 17;7(1):263.
2.Melero I, et al. Intratumoral co-injection of NK cells and NKG2A-neutralizing monoclonal antibodies. EMBO Mol Med. 2023 Nov 8;15(11):e17804.
3.Borel C, et al. Immunotherapy Breakthroughs in the Treatment of Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma. Cancers (Basel). 2020 Sep 21;12(9):2691.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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C1   V1   C2   V2