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验证数据展示

  • FC experiment of HeLa using 84733-6-RR (same clone as 84733-6-PBS)

    FC experiment of HeLa using 84733-6-RR (same clone as 84733-6-PBS)

    1x10^6 HeLa cells were intracellularly stained with 0.25 ug MXI1 Recombinant antibody (84733-6-RR, Clone:242089D5) and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2)(red), or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue). Cells were fixed and permeabilized with Transcription Factor Staining Buffer Kit (PF00011). This data was developed using the same antibody clone with 84733-6-PBS in a different storage buffer formulation.

  • IF Staining of SH-SY5Y using 84733-6-RR (same clone as 84733-6-PBS)

    IF Staining of SH-SY5Y using 84733-6-RR (same clone as 84733-6-PBS)

    Immunofluorescent analysis of (4% PFA) fixed SH-SY5Y cells using MXI1 antibody (84733-6-RR, Clone: 242089D5 ) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2), CL594-Phalloidin (red). This data was developed using the same antibody clone with 84733-6-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84733-6-RR

    Affinity and Kinetic Characterization of 84733-6-RR

    Biolayer interferometry (BLl) kinetic assays of 84733-6-RR against Human MXI1 were performed. The affinity constant is below 1 pM.

MXI1 Recombinant monoclonal antibody, PBS Only

MXI1 Uni-rAb® Recombinant Antibody for IF/ICC, FC (Intra), Indirect ELISA
Cat No. 84733-6-PBS

产品说明书

CloneNo. 242089D5

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

IF/ICC, FC (Intra), Indirect ELISA

别名

242089D5, bHLHc11, Class C basic helix-loop-helix protein 11, MAD2, Max interacting protein 1

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

84733-6-PBS targets MXI1 in IF/ICC, FC (Intra), Indirect ELISA applications and shows reactivity with human samples.

经测试应用 IF/ICC, FC (Intra), Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag3024

Product name: Recombinant human MXI1 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-182 aa of BC012907

Sequence: MPSPRLQHSKPPRRLSRAQKHSSGSSNTSTANRRAHLRLCLERLKVLIPLGPDCTRHTTLGLLNKAKAHIKKLEEAERKSQHQLENLEREQRFLKWRLEQLQGPQEMERIRMDSIGSTISSDRSDSEREEIEVDVESTEFSHGEVDNISTTSISDIDDHSSLPSIGSDEGYSSASVKLSFTS

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 MAX interactor 1
别名 242089D5, bHLHc11, Class C basic helix-loop-helix protein 11, MAD2, Max interacting protein 1
计算分子量228 aa, 26 kDa
GenBank蛋白编号BC012907
基因名称 MXI1
Gene ID (NCBI) 4601
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purfication
UNIPROT IDP50539
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

MXI1 is a transcription factor containing a basic helix-loop-helix leucine zipper (bHLHzip) and belongs to the Myc-Max-Mad transcriptional network. It is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors.

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