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验证数据展示

  • WB analysis of HeLa using 67312-1-Ig (same clone as 67312-1-PBS)

    WB analysis of HeLa using 67312-1-Ig (same clone as 67312-1-PBS)

    HeLa cells were subjected to SDS PAGE followed by western blot with 67312-1-Ig (MTMR2 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67312-1-PBS in a different storage buffer formulation.

  • WB analysis of HeLa using 67312-1-Ig (same clone as 67312-1-PBS)

    WB analysis of HeLa using 67312-1-Ig (same clone as 67312-1-PBS)

    WB result of MTMR2 antibody (67312-1-Ig; 1:2000; incubated at room temperature for 1.5 hours) with sh-Control and sh-MTMR2 transfected HeLa cells. This data was developed using the same antibody clone with 67312-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO验证

MTMR2 Monoclonal antibody, PBS Only

MTMR2 Monoclonal Antibody for WB, Indirect ELISA
Cat No. 67312-1-PBS

产品说明书

CloneNo. 1B11B7

宿主/亚型

Mouse / IgG2b

种属反应性

Human, Pig

应用

WB, Indirect ELISA

别名

CMT4B, CMT4B1, KIAA1073, MTMR2, myotubularin related protein 2

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

67312-1-PBS targets MTMR2 in WB, Indirect ELISA applications and shows reactivity with Human, Pig samples.

经测试应用 WB, Indirect ELISA Application Description
经测试反应性 Human, Pig
免疫原

CatNo: Ag28413

Product name: Recombinant human MTMR2 protein

Source: e coli.-derived, PET28a

Tag: 6*His

Domain: 294-643 aa of BC052990

Sequence: KRSKEDEKYLQAIMDSNAQSHKIFIFDARPSVNAVANKAKGGGYESEDAYQNAELVFLDIHNIHVMRESLRKLKEIVYPNIEETHWLSNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLAMLMLDGYYRTIRGFEVLVEKEWLSFGHRFQLRVGHGDKNHADADRSPVFLQFIDCVWQMTRQFPTAFEFNEYFLITILDHLYSCLFGTFLCNSEQQRGKENLPKRTVSLWSYINSQLEDFTNPLYGSYSNHVLYPVASMRHLELWVGYYIRWNPRMKPQEPIHNRYKELLAKRAELQKKVEELQREISNRSTSSSERASSPAQCVTPVQTVV

种属同源性预测
宿主/亚型 Mouse / IgG2b
抗体类别 Monoclonal
产品类型 Antibody
全称 myotubularin related protein 2
别名 CMT4B, CMT4B1, KIAA1073, MTMR2, myotubularin related protein 2
计算分子量 73 kDa
观测分子量 66-73 kDa
GenBank蛋白编号BC052990
基因名称 MTMR2
Gene ID (NCBI) 8898
RRIDAB_2882572
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purification
UNIPROT IDQ13614
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

MTMR2(myotubularin-related protein 2) is also named as KIAA1073 and belongs to the non-receptor class myotubularin subfamily, which is characterized by the presence of a phosphatase domain. It may regulate vesicular trafficking in Schwann cells (PMID:17880751) and its reversible phosphorylation represents a critical mechanism for regulating the subcellular localization of MTMR2(PMID:21372139). MTMR2 is a 73 kDa protein in its monomeric form and exist as a dimer within cells and the protein re-localizes to membranes in hypo-osmotic settings(PMID:16399794). Defects in MTMR2 are the cause of Charcot-Marie-Tooth disease type 4B1 (CMT4B1). MTMR2 has two isofroms with the molecular mass of 73 and 66 kDa.