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验证数据展示

  • WB analysis of HeLa using 67312-1-Ig

    WB analysis of HeLa using 67312-1-Ig

    HeLa cells were subjected to SDS PAGE followed by western blot with 67312-1-Ig (MTMR2 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours.

  • WB analysis of HeLa using 67312-1-Ig

    WB analysis of HeLa using 67312-1-Ig

    WB result of MTMR2 antibody (67312-1-Ig; 1:2000; incubated at room temperature for 1.5 hours) with sh-Control and sh-MTMR2 transfected HeLa cells.

  • Featured Product
  • KD/KO验证

MTMR2 Monoclonal antibody

MTMR2 Monoclonal Antibody for WB, ELISA
Cat No. 67312-1-Ig

产品说明书

CloneNo. 1B11B7

宿主/亚型

Mouse / IgG2b

种属反应性

Human, Pig

应用

WB, ELISA

别名

CMT4B, CMT4B1, KIAA1073, MTMR2, myotubularin related protein 2

缓冲液配方:  PBS and Azide
PBS and Azide
PBS Only
偶联物:  Unconjugated
Unconjugated
规格: 

-/ -

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经过测试的应用

Positive WB detected inHeLa cells, pig brain tissue, HEK-293 cells, Jurkat cells

推荐稀释比

应用推荐稀释比
Western Blot (WB)WB : 1:1000-1:6000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

67312-1-Ig targets MTMR2 in WB, ELISA applications and shows reactivity with Human, Pig samples.

经测试应用 WB, ELISA Application Description
经测试反应性 Human, Pig
免疫原 MTMR2 fusion protein Ag28413 种属同源性预测
宿主/亚型 Mouse / IgG2b
抗体类别 Monoclonal
产品类型 Antibody
全称 myotubularin related protein 2
别名 CMT4B, CMT4B1, KIAA1073, MTMR2, myotubularin related protein 2
计算分子量 73 kDa
观测分子量 66-73 kDa
GenBank蛋白编号BC052990
基因名称 MTMR2
Gene ID (NCBI) 8898
RRIDAB_2882572
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDQ13614
储存缓冲液 PBS with 0.02% sodium azide and 50% glycerol , pH 7.3
储存条件Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

MTMR2(myotubularin-related protein 2) is also named as KIAA1073 and belongs to the non-receptor class myotubularin subfamily, which is characterized by the presence of a phosphatase domain. It may regulate vesicular trafficking in Schwann cells (PMID:17880751) and its reversible phosphorylation represents a critical mechanism for regulating the subcellular localization of MTMR2(PMID:21372139). MTMR2 is a 73 kDa protein in its monomeric form and exist as a dimer within cells and the protein re-localizes to membranes in hypo-osmotic settings(PMID:16399794). Defects in MTMR2 are the cause of Charcot-Marie-Tooth disease type 4B1 (CMT4B1). MTMR2 has two isofroms with the molecular mass of 73 and 66 kDa.

实验方案

Product Specific Protocols
WB protocol for MTMR2 antibody 67312-1-IgDownload protocol
Standard Protocols
Click here to view our Standard Protocols