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验证数据展示

  • IP experiment of HeLa using 17600-1-AP (same clone as 17600-1-PBS)

    IP experiment of HeLa using 17600-1-AP (same clone as 17600-1-PBS)

    IP result of anti-MTMR15 (IP:17600-1-AP, 4ug; Detection:17600-1-AP 1:300) with HeLa cells lysate 2800 ug. This data was developed using the same antibody clone with 17600-1-PBS in a different storage buffer formulation.

  • WB analysis using 17600-1-AP (same clone as 17600-1-PBS)

    WB analysis using 17600-1-AP (same clone as 17600-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 17600-1-AP (MTMR15 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 17600-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO Validated

MTMR15/FAN1 Polyclonal antibody, PBS Only

MTMR15/FAN1 Polyclonal Antibody for WB, IP, Indirect ELISA
Cat No. 17600-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IP, Indirect ELISA

别名

MTMR15, EC:3.1.21.-, FAN1, FANCD2/FANCI-associated nuclease 1, Fanconi-associated nuclease 1

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

17600-1-PBS targets MTMR15/FAN1 in WB, IP, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IP, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag11651

Product name: Recombinant human MTMR15 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 186-534 aa of BC047882

Sequence: STVVKSLIDNSSEIEDEDQILENSSQKENVFKCDSLKEECIPEHMVRESKIMEAESQKATRECEKSALTPGFSDNAIMLFSPDFTLRNTLKSTSEDSLVKQECIKEVVEKREACHCEEVKMTVASEAKIQLSDSEAKSHSSADDASAWSNIQEAPLQDDSCLNNDIPHSIPLEQGSSCNGPGQTTGHPYYLRSFLVVLKTVLENEDDMLLFDEQEKGIVTKFYQLSATGQKLYVRLFQRKLSWIKMTKLEYEEIALDLTPVIEELTNAGFLQTESELQELSEVLELLSAPELKSLAKTFHLVNPNGQKQQLVDAFLKLAKQRSVCTWGKNKPGIGAVILKRFCWLLLQ

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 myotubularin related protein 15
别名 MTMR15, EC:3.1.21.-, FAN1, FANCD2/FANCI-associated nuclease 1, Fanconi-associated nuclease 1
计算分子量 60 kDa, 114 kDa
观测分子量 63-68 kDa, 120-140 kDa
GenBank蛋白编号BC047882
基因名称 MTMR15
Gene ID (NCBI) 22909
RRIDAB_10598016
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ9Y2M0
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

MTMR15, also named as FAN1 and KIAA1018, is a nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. It is specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates. MTMR15 has some isoforms with MW 114 kDa and 60 kDa. The MW will be migrated to 120-140 kDa and 63-68 kDa with modification.

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