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验证数据展示

  • WB analysis of Jurkat using 16705-1-AP (same clone as 16705-1-PBS)

    WB analysis of Jurkat using 16705-1-AP (same clone as 16705-1-PBS)

    WB result of MTH1 antibody (16705-1-AP; 1:4000; incubated at room temperature for 1.5 hours) with sh-Control and sh-MTH1 transfected Jurkat cells. This data was developed using the same antibody clone with 16705-1-PBS in a different storage buffer formulation.

  • WB analysis of HepG2 using 16705-1-AP (same clone as 16705-1-PBS)

    WB analysis of HepG2 using 16705-1-AP (same clone as 16705-1-PBS)

    HepG2 cells were subjected to SDS PAGE followed by western blot with 16705-1-AP (MTH1 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 16705-1-PBS in a different storage buffer formulation.

  • IF Staining of PC-3 using 16705-1-AP (same clone as 16705-1-PBS)

    IF Staining of PC-3 using 16705-1-AP (same clone as 16705-1-PBS)

    Immunofluorescent analysis of PC-3 cells using 16705-1-AP (MTH1 antibody) at dilution of 1:25 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). This data was developed using the same antibody clone with 16705-1-PBS in a different storage buffer formulation.

  • IHC staining of human lung cancer using 16705-1-AP (same clone as 16705-1-PBS)

    IHC staining of human lung cancer using 16705-1-AP (same clone as 16705-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human lung cancer tissue slide using 16705-1-AP (MTH1 antibody) at dilution of 1:4000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 16705-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with NUDT1/MTH1 antibody included
  • Featured Product
  • KD/KO Validated

MTH1 Polyclonal antibody, PBS Only

MTH1 Polyclonal Antibody for WB, IHC, IF/ICC, Indirect ELISA
Cat No. 16705-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, IF/ICC, Indirect ELISA

别名

NUDT1, 2-hydroxy-dATP diphosphatase, 7,8-dihydro-8-oxoguanine triphosphatase, 8 oxo dGTPase, 8-oxo-dGTPase

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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Planning an IHC experiment? We recommend our IHCeasy NUDT1/MTH1 Ready-To-Use IHC Kit. NUDT1/MTH1 primary antibody included.

产品信息

16705-1-PBS targets MTH1 in WB, IHC, IF/ICC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, IF/ICC, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag10103

Product name: Recombinant human NUDT1 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-179 aa of BC014618

Sequence: MSGISPQQMGEPEGSWSGKNPGTMGASRLYTLVLVLQPQRVLLGMKKRGFGAGRWNGFGGKVQEGETIEDGARRELQEESGLTVDALHKVGQIVFEFVGEPELMDVHVFCTDSIQGTPVESDEMRPCWFQLDQIPFKDMWPDDSYWFPLLLQKKKFHGYFKFQGQDTILDYTLREVDTV

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 nudix (nucleoside diphosphate linked moiety X)-type motif 1
别名 NUDT1, 2-hydroxy-dATP diphosphatase, 7,8-dihydro-8-oxoguanine triphosphatase, 8 oxo dGTPase, 8-oxo-dGTPase
计算分子量179aa,20 kDa; 197aa,23 kDa
观测分子量 18-24 kDa
GenBank蛋白编号BC014618
基因名称 MTH1
Gene ID (NCBI) 4521
RRIDAB_2153822
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDP36639
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

MTH1, also known as NUDT1 or 8-Oxo-dGTPase, is an important repair enzyme that prevents oxidative stress-induced DNA damage through hydrolyzing mutagenic 8-oxo-dGTP into 8-oxo-dGMP. MTH1 is expressed in postmitotic neurons as well as in proliferative tissues, and it is localized both in the mitochondria and nucleus. MTH1 might be a useful marker of oxidative stress and its level increased upon oxidative stress. Increased expression of MTH1 were also found in various cancer tissues and neurodegenerative diseases.

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