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验证数据展示

  • WB analysis using 86358-1-RR (same clone as 86358-1-PBS)

    WB analysis using 86358-1-RR (same clone as 86358-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 86358-1-RR (MSRA antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86358-1-PBS in a different storage buffer formulation.

  • IF Staining of THP-1 using 86358-1-RR (same clone as 86358-1-PBS)

    IF Staining of THP-1 using 86358-1-RR (same clone as 86358-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed THP-1 cells using MSRA antibody (86358-1-RR, Clone: 251025H2 ) at dilution of 1:200 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 86358-1-PBS in a different storage buffer formulation.

MSRA Recombinant monoclonal antibody, PBS Only

MSRA Uni-rAb® Recombinant Antibody for WB, IF/ICC, Indirect ELISA
Cat No. 86358-1-PBS

产品说明书

CloneNo. 251025H2

宿主/亚型

Rabbit / IgG

种属反应性

human, rat

应用

WB, IF/ICC, Indirect ELISA

别名

EC:1.8.4.11, Mitochondrial peptide methionine sulfoxide reductase, Peptide Met(O) reductase, Peptide-methionine, PMSR

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

86358-1-PBS targets MSRA in WB, IF/ICC, Indirect ELISA applications and shows reactivity with human, rat samples.

经测试应用 WB, IF/ICC, Indirect ELISA Application Description
经测试反应性 human, rat
免疫原

CatNo: Ag6053

Product name: Recombinant human MSRA protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-235 aa of BC054033

Sequence: MLSATRRACQLLLLHSLFPVPRMGNSASNIVSPQEALPGRKEQTPVAAKHHVNGNRTVEPFPEGTQMAVFGMGCFWGAERKFWVLKGVYSTQVGFAGGYTSNPTYKEVCSEKTGHAEVVRVVYQPEHMSFEELLKVFWENHDPTQGMRQGNDHGTQYRSAIYPTSAKQMEAALSSKENYQKVLSEHGFGPITTDIREGQTFYYAEDYHQQYLSKNPNGYCGLGGTGVSCPVGIKK

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 methionine sulfoxide reductase A
别名 EC:1.8.4.11, Mitochondrial peptide methionine sulfoxide reductase, Peptide Met(O) reductase, Peptide-methionine, PMSR
计算分子量 26 kDa
观测分子量 24-26 kDa
GenBank蛋白编号BC054033
基因名称 MSRA
Gene ID (NCBI) 4482
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purification
UNIPROT IDQ9UJ68
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Methionine sulfoxide reductase A (MSRA) is an antioxidant enzyme found in all domains of life that catalyzes the reduction of methionine-S-sulfoxide (MSO) to methionine in proteins and free amino acids (PMID: 28874471). MSRA has some isoforms with MW of 19~26 kDa. MSRA functions in the repair of oxidatively damaged proteins to restore biological activity. Transfection of MSRA reduced colony formation and the invasiveness of HCC cell lines. Studies have demonstrated the downregulation of MSRA in multiple human tumors, including breast cancers and its levels have been linked to advanced tumor grades (PMID: 20937881).

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