ABCC5 Polyclonal antibody
ABCC5 Polyclonal Antibody for WB, ELISA
Host / Isotype
Rabbit / IgG
Reactivity
Human
Applications
WB, ELISA
Conjugate
Unconjugated
验证数据展示
经过测试的应用
Positive WB detected in | MCF-7 cells, unboiled HepG2 cells, unboiled MCF-7 cells |
推荐稀释比
Application | Dilution |
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Western Blot (WB) | WB : 1:500-1:2000 |
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Sample-dependent, Check data in validation data gallery. |
产品信息
29792-1-AP targets ABCC5 in WB, ELISA applications and shows reactivity with Human samples.
Tested Applications | WB, ELISA |
Tested Reactivity | Human |
Immunogen | ABCC5 fusion protein Ag31680 种属同源性预测 |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Full Name | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 |
Synonyms | ABC33, ABCC5, DKFZp686C1782, EST277145, MOAT C, MOATC, MRP5, pABC11, SMRP |
Calculated Molecular Weight | 161 kDa |
Observed Molecular Weight | 161-200 kDa |
GenBank Accession Number | NM_005688 |
Gene Symbol | ABCC5 |
Gene ID (NCBI) | 10057 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Antigen affinity purification |
UNIPROT ID | O15440 |
Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
ABCC5, also named as MOAT-C, pABC11, SMRP and MRP5, belongs to the ABC transporter superfamily, ABCC family and Conjugate transporter (TC 3.A.1.208) subfamily. ABCC5 acts as a multispecific organic anion pump which can transport nucleotide analogs. ABCC5 functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that ABCC5 provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl) adenine. ABCC5 may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear. Since it is glycosylated, the apparent molecular weight of ABCC5 could be variable, ranging from 161 kDa to 200 kDa (PMID: 10893247; PMID: 15897250; PMID: 31338999).
实验方案
Product Specific Protocols | |
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WB protocol for ABCC5 antibody 29792-1-AP | Download protocol |
Standard Protocols | |
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Click here to view our Standard Protocols |