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验证数据展示

  • WB analysis using 10744-1-AP (same clone as 10744-1-PBS)

    WB analysis using 10744-1-AP (same clone as 10744-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 10744-1-AP (MRE11 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 10744-1-PBS in a different storage buffer formulation.

  • IHC staining of human lymphoma using 10744-1-AP (same clone as 10744-1-PBS)

    IHC staining of human lymphoma using 10744-1-AP (same clone as 10744-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human lymphoma using 10744-1-AP (MRE11 antibody) at dilution of 1:50 (under 10x lens). This data was developed using the same antibody clone with 10744-1-PBS in a different storage buffer formulation.

  • IP experiment of HeLa using 10744-1-AP (same clone as 10744-1-PBS)

    IP experiment of HeLa using 10744-1-AP (same clone as 10744-1-PBS)

    IP result of anti-MRE11 (IP:10744-1-AP, 4ug; Detection:10744-1-AP 1:1000) with HeLa cells lysate 960 ug. This data was developed using the same antibody clone with 10744-1-PBS in a different storage buffer formulation.

MRE11 Polyclonal antibody, PBS Only

MRE11 Polyclonal Antibody for WB, IHC, IP, Indirect ELISA
Cat No. 10744-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, IP, Indirect ELISA

别名

MRE11A, ATLD, Double-strand break repair protein MRE11, EC:3.1.-.-, HNGS1

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

10744-1-PBS targets MRE11 in WB, IHC, IP, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, IP, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag1105

Product name: Recombinant human MRE11A protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-206 aa of BC005241

Sequence: MSTADALDDENTFKILVATDIHLGFMEKDAVRGNDTFVTLDEILRLAQENEVDFILLGGDLFHENKPSRKTLHTCLELLRKYCMGDRPVQFEILSDQSVNFGFSKFPWVNYQDGNLNISIPVFSIHGNHDDPTGADALCALDILSCAGFVNHFGRSMSVEKIDISPVLLQKGSTKIALYGLGSIPDERLYRMFVNKKVTMLRPKED

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
别名 MRE11A, ATLD, Double-strand break repair protein MRE11, EC:3.1.-.-, HNGS1
计算分子量 81 kDa
观测分子量 81 kDa
GenBank蛋白编号BC005241
基因名称 MRE11A
Gene ID (NCBI) 4361
RRIDAB_2145118
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDP49959
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Mre11 (meiotic recombination 11), also named as Mre11A, is a component of the MRN( MRE11/RAD50/NBS1) complex which is a versatile complex, playing a key role in the sensing, processing, and repair of DSBs. MRE11 possesses both endonuclease and 3'-5' exonuclease activity. It contains two DNA-binding domains (DBDs), enabling it to bind both single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). After DSBs, MRE11 is loaded onto DSBs sites and cleaves DNA by cooperating with CtIP (CtBP [C terminal binding protein] interacting protein) to initiate end resection. It's reported that MRE11 is over-expressed in breast cancers. (PMID:38128537; 22914783)

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