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验证数据展示

  • WB analysis using 86910-3-RR (same clone as 86910-3-PBS)

    WB analysis using 86910-3-RR (same clone as 86910-3-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 86910-3-RR (MOF antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86910-3-PBS in a different storage buffer formulation.

  • IF Staining of HCT 116 using 86910-3-RR (same clone as 86910-3-PBS)

    IF Staining of HCT 116 using 86910-3-RR (same clone as 86910-3-PBS)

    Immunofluorescent analysis of (4% PFA) fixed HCT 116 cells using MOF antibody (86910-3-RR, Clone: 251926C5 ) at dilution of 1:1200 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2), CL594-Phalloidin (red). This data was developed using the same antibody clone with 86910-3-PBS in a different storage buffer formulation.

  • FC experiment of HepG2 using 86910-3-RR (same clone as 86910-3-PBS)

    FC experiment of HepG2 using 86910-3-RR (same clone as 86910-3-PBS)

    1x10^6 HepG2 cells were intracellularly stained with 0.25 ug MOF Recombinant monoclonal antibody (86910-3-RR, Clone:251926C5) and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2)(red), or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue). Cells were fixed and permeabilized with Transcription Factor Staining Buffer Kit (PF00011). This data was developed using the same antibody clone with 86910-3-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 86910-3-RR

    Affinity and Kinetic Characterization of 86910-3-RR

    Biolayer interferometry (BLl) kinetic assays of 86910-3-RR against Human MOF were performed. The affinity constant is below 1 pM.

MOF Recombinant monoclonal antibody, PBS Only

MOF Uni-rAb® Recombinant Antibody for WB, IF/ICC, FC (Intra), Indirect ELISA
Cat No. 86910-3-PBS

产品说明书

CloneNo. 251926C5

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IF/ICC, FC (Intra), Indirect ELISA

别名

MYST1, EC:2.3.1.-, EC:2.3.1.48, Histone acetyltransferase KAT8, hMOF

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

86910-3-PBS targets MOF in WB, IF/ICC, FC (Intra), Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IF/ICC, FC (Intra), Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag4802

Product name: Recombinant human MOF protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 118-467 aa of BC037773

Sequence: AVQKNSEKYLSELAEQPERKITRNQKRKHDEINHVQKTYAEMDPTTAALEKEHEAITKVKYVDKIHIGNYEIDAWYFSPFPEDYGKQPKLWLCEYCLKYMKYEKSYRFHLGQCQWRQPPGKEIYRKSNISVYEVDGKDHKIYCQNLCLLAKLFLDHKTLYFDVEPFVFYILTEVDRQGAHIVGYFSKEKESPDGNNVACILTLPPYQRRGYGKFLIAFSYELSKLESTVGSPEKPLSDLGKLSYRSYWSWVLLEILRDFRGTLSIKDLSQMTSITQNDIISTLQSLNMVKYWKGQHVICVTPKLVEEHLKSAQYKKPPITGGWGAAVCRGRWGSVSMWTGRSQGLLIAVT

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 MYST histone acetyltransferase 1
别名 MYST1, EC:2.3.1.-, EC:2.3.1.48, Histone acetyltransferase KAT8, hMOF
计算分子量 467 aa, 53 kDa
观测分子量52 kDa
GenBank蛋白编号BC037773
基因名称 KAT8/MOF
Gene ID (NCBI) 84148
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purification
UNIPROT IDQ9H7Z6
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

MOF, also known as MYST1, KAT8, is a member of the MYST acetyltransferase family, which is homologous to Drosophila males absent on the first (MOF) protein. Deletion of MYST1 in cells leads to genomic instability, spontaneous chromosomal aberration, cell cycle defects, reduced transcription of certain genes and defective DNA damage repair (PMID: 32711345). MYST1 dually localizes to the nucleus and mitochondria of human cancer cells (PMID: 37813994).

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