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验证数据展示

  • WB analysis of HeLa using 23742-1-AP (same clone as 23742-1-PBS)

    WB analysis of HeLa using 23742-1-AP (same clone as 23742-1-PBS)

    HeLa cells were subjected to SDS PAGE followed by western blot with 23742-1-AP (MNT antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 23742-1-PBS in a different storage buffer formulation.

  • WB analysis of HeLa using 23742-1-AP (same clone as 23742-1-PBS)

    WB analysis of HeLa using 23742-1-AP (same clone as 23742-1-PBS)

    WB result of MNT antibody (23742-1-AP; 1:2000; incubated at room temperature for 1.5 hours) with sh-Control and sh-MNT transfected HeLa cells. This data was developed using the same antibody clone with 23742-1-PBS in a different storage buffer formulation.

  • IF Staining of HeLa using 23742-1-AP (same clone as 23742-1-PBS)

    IF Staining of HeLa using 23742-1-AP (same clone as 23742-1-PBS)

    Immunofluorescent analysis of (-20℃ Ethanol) fixed HeLa cells using 23742-1-AP (MNT antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). This data was developed using the same antibody clone with 23742-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO Validated

MNT Polyclonal antibody, PBS Only

MNT Polyclonal Antibody for WB, IF/ICC, Indirect ELISA
Cat No. 23742-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IF/ICC, Indirect ELISA

别名

bHLHd3, Class D basic helix-loop-helix protein 3, MAD6, MAX binding protein, Max binding protein MNT

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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Planning an IHC experiment? We recommend our IHCeasy MNT Ready-To-Use IHC Kit. MNT primary antibody included.

产品信息

23742-1-PBS targets MNT in WB, IF/ICC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IF/ICC, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag20666

Product name: Recombinant human MNT protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 233-582 aa of BC117563

Sequence: RAHLKECFETLKRNIPNVDDKKTSNLSVLRTALRYIQSLKRKEKEYEHEMERLAREKIATQQRLAELKHELSQWMDVLEIDRVLRQTGQPEDDQASTSTASEGEDNIDEDMEEDRAGLGPPKLSHRPQPELLKSTLPPPSTTPAPLPPHPHPHPHSVALPPAHLPVQQQQPQQKTPLPAPPPPPAAPAQTLVPAPAHLVATAGGGSTVIAHTATTHASVIQTVNHVLQGPGGKHIAHIAPSAPSPAVQLAPATPPIGHITVHPATLNHVAHLGSQLPLYPQPVAVSHIAHTLSHQQVNGTAGLGPPATVMAKPAVGAQVVHHPQLVGQTVLNPVTMVTMPSFPVSTLKLA

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 MAX binding protein
别名 bHLHd3, Class D basic helix-loop-helix protein 3, MAD6, MAX binding protein, Max binding protein MNT
计算分子量 582 aa, 62 kDa
观测分子量 70 kDa
GenBank蛋白编号BC117563
基因名称 MNT
Gene ID (NCBI) 4335
RRIDAB_2879314
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen Affinity purified
UNIPROT IDQ99583
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Mnt (Max binding protein), also known as MAD6, ROX, bHLHd3 (class D basic helix-loop-helix protein 3) or MXD6, is a 582 amino acid nuclear protein that forms a complex with Max (Myc-associated factor X) to repress transcription. Mnt contains one basic helix-loop-helix (bHLH) domain and is encoded by a gene that maps to human chromosome 17p13.3. Chromosome 17 comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.

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