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验证数据展示

  • WB analysis using 60055-1-Ig (same clone as 60055-1-PBS)

    WB analysis using 60055-1-Ig (same clone as 60055-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 60055-1-Ig (MGP antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 60055-1-PBS in a different storage buffer formulation.

  • IHC staining of human colon cancer using 60055-1-Ig (same clone as 60055-1-PBS)

    IHC staining of human colon cancer using 60055-1-Ig (same clone as 60055-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using 60055-1-Ig (MGP antibody) at dilution of 1:800 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 60055-1-PBS in a different storage buffer formulation.

  • IHC staining of human gliomas using 60055-1-Ig (same clone as 60055-1-PBS)

    IHC staining of human gliomas using 60055-1-Ig (same clone as 60055-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human gliomas tissue slide using 60055-1-Ig (MGP Antibody) at dilution of 1:800 (under 10x lens). This data was developed using the same antibody clone with 60055-1-PBS in a different storage buffer formulation.

  • IHC staining of human gliomas using 60055-1-Ig (same clone as 60055-1-PBS)

    IHC staining of human gliomas using 60055-1-Ig (same clone as 60055-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human gliomas tissue slide using 60055-1-Ig (MGP Antibody) at dilution of 1:800 (under 40x lens). This data was developed using the same antibody clone with 60055-1-PBS in a different storage buffer formulation.

  • IF Staining of mouse kidney using 60055-1-Ig (same clone as 60055-1-PBS)

    IF Staining of mouse kidney using 60055-1-Ig (same clone as 60055-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed mouse kidney tissue using MGP antibody (60055-1-Ig, Clone: 1A1C3 ) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Mouse IgG(H+L). This data was developed using the same antibody clone with 60055-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO验证

MGP Monoclonal antibody, PBS Only

MGP Monoclonal Antibody for WB, IHC, IF-P, Indirect ELISA
Cat No. 60055-1-PBS

产品说明书

CloneNo. 1A1C3

宿主/亚型

Mouse / IgG2a

种属反应性

human, mouse

应用

WB, IHC, IF-P, Indirect ELISA

别名

GIG36, MGLAP, matrix Gla protein, Cell growth-inhibiting gene 36 protein, 1A1C3

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

60055-1-PBS targets MGP in WB, IHC, IF-P, Indirect ELISA applications and shows reactivity with human, mouse samples.

经测试应用 WB, IHC, IF-P, Indirect ELISA Application Description
经测试反应性 human, mouse
免疫原 MGP fusion protein Ag1091 种属同源性预测
宿主/亚型 Mouse / IgG2a
抗体类别 Monoclonal
产品类型 Antibody
全称 matrix Gla protein
别名 GIG36, MGLAP, matrix Gla protein, Cell growth-inhibiting gene 36 protein, 1A1C3
计算分子量 103 aa, 13 kDa
观测分子量 12 kDa
GenBank蛋白编号BC005272
基因名称 MGP
Gene ID (NCBI) 4256
RRIDAB_2143330
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDP08493
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Matrix Gla protein (MGP) is is a vitamin K-dependent, extracellular matrix protein. MGP plays a pivotal role in preventing soft tissue calcification and local mineralization of the vascular wall. Vitamin K deficiency leads to inactive uncarboxylated MGP (ucMGP), which accumulates at sites of arterial calcification. However MGP is synthesized in many tissues and is especially enriched in embryonic tissues and in cancer cells. Defects in MGP are the cause of Keutel syndrome (KS), which is an autosomal recessive disorder characterized by abnormal cartilage calcification, peripheral pulmonary stenosis neural hearing loss and midfacial hypoplasia.