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MACC1 Polyclonal antibody

MACC1 Polyclonal Antibody for IHC, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

IHC, ELISA

Conjugate

Unconjugated

Cat No : 21970-1-AP

Print datasheet

Synonyms

7A5, MACC1, SH3BP4L

验证数据展示

  • IHC staining of human liver cancer using 21970-1-AP

    IHC staining of human liver cancer using 21970-1-AP

    Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using 21970-1-AP (MACC1 Antibody) at dilution of 1:50 (under 10x lens).

  • IHC staining of human liver cancer using 21970-1-AP

    IHC staining of human liver cancer using 21970-1-AP

    Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using 21970-1-AP (MACC1 Antibody) at dilution of 1:50 (under 40x lens).

经过测试的应用

Positive IHC detected inhuman liver cancer tissue, human colon cancer tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

推荐稀释比

ApplicationDilution
Immunohistochemistry (IHC)IHC : 1:20-1:200
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

21970-1-AP targets MACC1 in IHC, ELISA applications and shows reactivity with human, mouse samples.

Tested Applications IHC, ELISA
Tested Reactivity human, mouse
Immunogen MACC1 fusion protein Ag16884 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name metastasis associated in colon cancer 1
Synonyms 7A5, MACC1, SH3BP4L
Calculated Molecular Weight 852 aa, 97 kDa
GenBank Accession NumberBC137090
Gene Symbol MACC1
Gene ID (NCBI) 346389
RRIDAB_2878957
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDQ6ZN28
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

MACC1, Metalloantigenolytic Cleavage Cartilage Proteinase 1, belongs to the ADAM (a disintegrin and metalloprotease) family. MACC1 was first identified in colon cancer. It is a key prognostic biomarker and is involved in recurrence, metastasis, and survival in solid cancers (PMID: 23815185). MACC1 expression is primarily observed in cartilage, but it's also present in other tissues like bone, synovium, and the developing nervous system (PMID: 36979146).

实验方案

Product Specific Protocols
IHC protocol for MACC1 antibody 21970-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

发表文章

SpeciesApplicationTitle

Mol Carcinog

The role of metastasis-associated in colon cancer 1 (MACC1) in endometrial carcinoma tumorigenesis and progression.

Authors - Shuo Chen
View Article