验证数据展示
产品信息
18842-1-PBS targets LPPR5 in IHC, Indirect ELISA applications and shows reactivity with human, mouse samples.
| 经测试应用 | IHC, Indirect ELISA Application Description |
| 经测试反应性 | human, mouse |
| 免疫原 |
Peptide 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | phosphatidic acid phosphatase type 2 |
| 别名 | PAP2D, Lipid phosphate phosphatase-related protein type 5, PAP2, Phosphatidic acid phosphatase type 2d, Phospholipid phosphatase-related protein type 5 |
| 计算分子量 | 35 kDa |
| GenBank蛋白编号 | NM_001010861 |
| 基因名称 | PAP2D |
| Gene ID (NCBI) | 163404 |
| RRID | AB_3741956 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | Q32ZL2 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
The lipid phosphate phosphatase-related proteins (LPPRs), also known as plasticity-related genes (PRGs), are a family of six transmembrane proteins that are enriched in brain. To date, five members have been identified (LPPR1-LPPR5). LPPR5 is an integral membrane protein linked to neuronal plasticity, which impedes NogoA- and LPA-mediated RhoA kinase signaling. LPPR5 modulates the Rho-GTPase pathway involved in cancer growth, vascularization, and the adaptive response to changes in the microenvironment. LPPR5 is pivotal in influencing growth, angiogenesis, and therapeutic resistance. (PMID: 26183180, PMID: 35328529)
