验证数据展示
产品信息
CL488-67139 targets LOXL2 in applications and shows reactivity with human samples.
| 经测试应用 | Application Description |
| 经测试反应性 | human |
| 免疫原 |
CatNo: Ag28566 Product name: Recombinant human LOXL2 protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 129-293 aa of BC000594 Sequence: TGNEATLAACTSNGWGVTDCKHTEDVGVVCSDKRIPGFKFDNSLINQIENLNIQVEDIRIRAILSTYRKRTPVMEGYVEVKEGKTWKQICDKHWTAKNSRVVCGMFGFPGERTYNTKVYKMFASRRKQRYWPFSMDCTGTEAHISSCKLGPQVSLDPMKNVTCEN 种属同源性预测 |
| 宿主/亚型 | Mouse / IgG2a |
| 抗体类别 | Monoclonal |
| 产品类型 | Antibody |
| 全称 | lysyl oxidase-like 2 |
| 别名 | 1H7F1, EC:1.4.3.13, LOR2, Lysyl oxidase-related protein WS9-14, WS9 14 |
| 计算分子量 | 774 aa, 87 kDa |
| 观测分子量 | 100 kDa |
| GenBank蛋白编号 | BC000594 |
| 基因名称 | LOXL2 |
| Gene ID (NCBI) | 4017 |
| RRID | AB_3084313 |
| 偶联类型 | CoraLite® Plus 488 Fluorescent Dye |
| 最大激发/发射波长 | 493 nm / 522 nm |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | Q9Y4K0 |
| 储存缓冲液 | PBS with 50% glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3. |
| 储存条件 | Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
LOXL2, also named as WS9-14, belongs to an amine oxidase family whose members have been implicated in crosslink formation in stromal collagens and elastin, cell motility, and tumor development and progression. LOXL2 activity might be a crucial modulator of Snail, providing an additional control mechanism of EMT and tumor progression. Increased LOXL2 expression in colon and esophageal cancer may contribute to tumor progression. We detected a band about 100 kd which is a secretory mature LOXL2 protein modified by glycosylation (PMID: 24014025).