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验证数据展示

  • WB analysis using 15993-1-AP (same clone as 15993-1-PBS)

    WB analysis using 15993-1-AP (same clone as 15993-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 15993-1-AP (LLGL2 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 15993-1-PBS in a different storage buffer formulation.

  • IF Staining of HepG2 using 15993-1-AP (same clone as 15993-1-PBS)

    IF Staining of HepG2 using 15993-1-AP (same clone as 15993-1-PBS)

    Immunofluorescent analysis of (-20°C Ethanol) fixed HepG2 cells using LLGL2 antibody (15993-1-AP) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L), CL594-phalloidin (red). This data was developed using the same antibody clone with 15993-1-PBS in a different storage buffer formulation.

  • IHC staining of human ovarian cancer using 15993-1-AP (same clone as 15993-1-PBS)

    IHC staining of human ovarian cancer using 15993-1-AP (same clone as 15993-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human ovarian cancer slide using 15993-1-AP (LLGL2 antibody) at dilution of 1:400 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 15993-1-PBS in a different storage buffer formulation.

LLGL2 Polyclonal antibody, PBS Only

LLGL2 Polyclonal Antibody for WB, IHC, IF/ICC, Indirect ELISA
Cat No. 15993-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IHC, IF/ICC, Indirect ELISA

别名

HGL, Lethal(2) giant larvae protein homolog 2, LLGL scribble cell polarity complex component 2

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

15993-1-PBS targets LLGL2 in WB, IHC, IF/ICC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IHC, IF/ICC, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag8867

Product name: Recombinant human LLGL2 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-356 aa of BC010879

Sequence: MRRFLRPGHDPVRERLKRDLFQFNKTVEHGFPHQPSALGYSPSLRILAIGTRSGAIKLYGAPGVEFMGLHQENNAVTQIHLLPGQCQLVTLLDDNSLHLWSLKVKGGASELQEDESFTLRGPPGAAPSATQITVVLPHSSCELLYLGTESGNVFVVQLPAFRALEDRTISSDAVLQRLPEEARHRRVFEMVEALQEHPRDPNQILIGYSRGLVVIWDLQGSRVLYHFLSSQQLENIWWQRDGRLLVSCHSDGSYCQWPVSSEAQQPEPLRSLVPYGPFPCKAITRILWLTTRQGLPFTIFQGGMPRASYGDRHCISVIHDGQQTAFDFTSRVIGFTVLTEADPAASRRASGVGAQG

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 lethal giant larvae homolog 2 (Drosophila)
别名 HGL, Lethal(2) giant larvae protein homolog 2, LLGL scribble cell polarity complex component 2
计算分子量356aa,40 kDa; 1020aa,113 kDa
观测分子量113-120 kDa
GenBank蛋白编号BC010879
基因名称 LLGL2
Gene ID (NCBI) 3993
RRIDAB_3085478
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ6P1M3
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Lethal giant larvae (Lgl) is a scaffolding protein that regulates the establishment of apical-basal polarity in epithelial cells. The human homologs of Lgl are known as LLGL1 and LLGL2. LLGL1 is a tumor suppressor in multiple human cancers, including hepatocellular carcinoma, malignant melanoma, and colorectal cancer (PMID: 34178676; 15735678; 16170365). LLGL2 functions as a promoter of tumor growth and not as a tumor suppressor in ER+ breast cancer (PMID: 30996345).

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