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验证数据展示

  • FC experiment of Transfected CHO cells using 98625-2-RR (same clone as 98625-2-PBS)

    FC experiment of Transfected CHO cells using 98625-2-RR (same clone as 98625-2-PBS)

    1x10^6 CHO cells or Lepr tansfected CHO cells were surface stained with 0.25 ug Anti-Mouse LEPR Rabbit RecAb (98625-2-RR, Clone:250779C11), or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) , and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98625-2-PBS in a different storage buffer formulation.

  • FC experiment of Transfected CHO cells using 98625-2-RR (same clone as 98625-2-PBS)

    FC experiment of Transfected CHO cells using 98625-2-RR (same clone as 98625-2-PBS)

    1x10^6 CHO cells or Lepr tansfected CHO cells were surface stained with 0.25 ug Anti-Mouse LEPR Rabbit RecAb (98625-2-RR, Clone:250779C11) (red), or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98625-2-PBS in a different storage buffer formulation.

  • Affinity of 98625-2-RR

    Affinity of 98625-2-RR

    Biolayer interferometry (BLl) kinetic assays of 98625-2-RR against Mouse LEPR were performed. The affinity constant is 5.30 nM.

Anti-Mouse LEPR Rabbit Recombinant Antibody, PBS Only

LEPR Uni-rAb® Recombinant Antibody for FC
Cat No. 98625-2-PBS

产品说明书

CloneNo. 250779C11

宿主/亚型

Rabbit / IgG

种属反应性

mouse

应用

FC

别名

B219, CD295, Db, LEP-R, Leptin receptor

缓冲液配方:  PBS Only
PBS, Azide
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

98625-2-PBS targets LEPR in FC applications and shows reactivity with mouse samples.

经测试应用 FC Application Description
经测试反应性 mouse
免疫原

CatNo: Eg2930

Product name: Recombinant Mouse Lepr protein (rFc Tag) (HPLC verified)

Source: mammalian cells-derived, V37

Tag: C-rFc

Domain: 22-839 aa of NM_146146.2

Sequence: LNLAYPISPWKFKLFCGPPNTTDDSFLSPAGAPNNASALKGASEAIVEAKFNSSGIYVPELSKTVFHCCFGNEQGQNCSALTDNTEGKTLASVVKASVFRQLGVNWDIECWMKGDLTLFICHMEPLPKNPFKNYDSKVHLLYDLPEVIDDSPLPPLKDSFQTVQCNCSLRGCECHVPVPRAKLNYALLMYLEITSAGVSFQSPLMSLQPMLVVKPDPPLGLHMEVTDDGNLKISWDSQTMAPFPLQYQVKYLENSTIVREAAEIVSATSLLVDSVLPGSSYEVQVRSKRLDGSGVWSDWSSPQVFTTQDVVYFPPKILTSVGSNASFHCIYKNENQIISSKQIVWWRNLAEKIPEIQYSIVSDRVSKVTFSNLKATRPRGKFTYDAVYCCNEQACHHRYAELYVIDVNINISCETDGYLTKMTCRWSPSTIQSLVGSTVQLRYHRRSLYCPDSPSIHPTSEPKNCVLQRDGFYECVFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSNVKAEITVNTGLLKVSWEKPVFPENNLQFQIRYGLSGKEIQWKTHEVFDAKSKSASLLVSDLCAVYVVQVRCRRLDGLGYWSNWSSPAYTLVMDVKVPMRGPEFWRKMDGDVTKKERNVTLLWKPLTKNDSLCSVRRYVVKHRTAHNGTWSEDVGNRTNLTFLWTEPAHTVTVLAVNSLGASLVNFNLTFSWPMSKVSAVESLSAYPLSSSCVILSWTLSPDDYSLLYLVIEWKILNEDDGMKWLRIPSNVKKFYIHDNFIPIEKYQFSLYPVFMEGVGKPKIINGFTKDAIDKQQNDAG

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 leptin receptor
别名 B219, CD295, Db, LEP-R, Leptin receptor
计算分子量131 kDa
GenBank蛋白编号NM_146146.2
基因名称 Lepr
Gene ID (NCBI) 16847
RRIDAB_3746224
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purification
UNIPROT IDP48356-1
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Leptin receptor (LEPR) is a protein-coding gene that encodes a receptor for leptin, an adipocyte-specific hormone that regulates body weight and fat metabolism (PMID: 11861497; 16333525). LEPR is involved in various physiological processes, including energy homeostasis, immune function, and hematopoiesis (PMID: 11923481; 25383904). It activates the JAK2/STAT3 signaling pathway, which is crucial for mediating leptin's effects on gene transcription and cellular responses (PMID: 11923481). LEPR also plays a role in the regulation of lipid metabolism, blood pressure, and blood glucose levels (PMID: 29254602).

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