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LAPTM4B Polyclonal antibody

LAPTM4B Polyclonal Antibody for WB, IHC, ELISA
Cat No. 18895-1-AP

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, ELISA and More (1)

LAPTM4B, LAPTM4beta, LC27

缓冲液配方:  PBS and Azide
PBS and Azide
偶联物:  Unconjugated
Unconjugated
规格: 

-/ -


经过测试的应用

Positive WB detected inmouse lymph tissue, rat lymph tissue
Positive IHC detected inhuman liver cancer tissue, human heart tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

推荐稀释比

应用推荐稀释比
Western Blot (WB)WB : 1:500-1:2000
Immunohistochemistry (IHC)IHC : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

18895-1-AP targets LAPTM4B in WB, IF, IHC, ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, ELISA Application Description
文献引用应用WB, IF, IHC
经测试反应性 human, mouse, rat
文献引用反应性human
免疫原 LAPTM4B fusion protein Ag13521 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 lysosomal protein transmembrane 4 beta
别名 LAPTM4B, LAPTM4beta, LC27
计算分子量 41 kDa
观测分子量 24 kDa
GenBank蛋白编号BC014129
基因名称 LAPTM4B
Gene ID (NCBI) 55353
RRIDAB_10597385
偶联类型 Unconjugated
形式 Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ86VI4
储存缓冲液 PBS with 0.02% sodium azide and 50% glycerol , pH 7.3
储存条件Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

LAPTM4B, a novel oncoprotein, is associated with the prognosis of cancer, and may play important roles in the initiation, promotion and metastasis of tumors. It was initially identified as a hepatocellular carcinoma-associated gene, and was recently shown to be up-regulated in various human cancers. Some studies indicated that LAPTM4B may be an useful marker of prognosis in ovarian carcinoma and endometrial cancer. LAPTM4B belongs to the LAPTM4/LAPTM5 transporter family. It has 3 isoforms with molecular masses 41 kDa, 35 kDa and 24 kDa. This antibody can recognize all the 3 isoforms of LAPTM4B.

实验方案

Product Specific Protocols
WB protocol for LAPTM4B antibody 18895-1-APDownload protocol
IHC protocol for LAPTM4B antibody 18895-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

发表文章

SpeciesApplicationTitle
humanWB, IF

Cell

A kinase-independent role for EGF receptor in autophagy initiation.

Authors - Xiaojun Tan
  • KD Validated
WB

Nat Commun

LAPTM4b recruits the LAT1-4F2hc Leu transporter to lysosomes and promotes mTORC1 activation.

Authors - Ruth Milkereit
humanIF

Proc Natl Acad Sci U S A

PtdIns(4,5)P2 signaling regulates ATG14 and autophagy.

Authors - Xiaojun Tan
IHC

Front Cell Dev Biol

Integrative Genome-Wide DNA Methylome and Transcriptome Analysis of Ovaries from Hu Sheep with High and Low Prolific.

Authors - Xiaolei Yao
humanWB,IHC,IF

Biochem Biophys Res Commun

Helicobacter pylori infection promotes epithelial-to-mesenchymal transition of gastric cells by upregulating LAPTM4B.

Authors - Shengfei Zhou
  • KD Validated
humanIF

Cancer Manag Res

LAPTM4B facilitates tumor growth and induces autophagy in hepatocellular carcinoma.

Authors - Fei Wang
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