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验证数据展示

  • FC experiment of human PBMCs using CL594-98326

    FC experiment of human PBMCs using CL594-98326

    1x10^6 FC receptor blocked human PBMCs were surface stained with CoraLite® Plus 488 Anti-Human CD19, and 5 ul CoraLite®594 Anti-Human LAIR1 Rabbit RecAb (CL594-98326, Clone: 241805G2) or CoraLite®594 Rabbit IgG Isotype Control RecAb (CL594-98136, Clone: 240953C9).Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed.

  • FC experiment of human PBMCs using CL594-98326

    FC experiment of human PBMCs using CL594-98326

    1x10^6 FC receptor blocked human PBMCs were surface stained with 5 ul CoraLite®594 Anti-Human LAIR1 Rabbit RecAb (CL594-98326, Clone: 241805G2) (red) or CoraLite®594 Rabbit IgG Isotype Control RecAb (CL594-98136, Clone: 240953C9) (blue). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed.

CoraLite®594 Anti-Human LAIR1 Rabbit Recombinant Antibody

LAIR1 Recombinant Antibody for FC
Cat No. CL594-98326

产品说明书

CloneNo. 241805G2

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

FC

别名

241805G2, CD305, hLAIR1, LAIR 1, LAIR-1

缓冲液配方:  PBS and Azide
PBS and Azide
偶联物:  CoraLite®594
规格价格库存

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经过测试的应用

Positive FC detected inhuman PBMCs
For other applications, we recommend the unconjugated version of this antibody, 98326-1-PBS

推荐稀释比

应用推荐稀释比
Flow Cytometry (FC)FC : 5 ul per 10^6 cells in a 100 µl suspension
This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is 5 ul per 10^6 cells in a 100 µl suspension or 5 ul per 100 µl of whole blood.
Sample-dependent, Check data in validation data gallery.

产品信息

CL594-98326 targets LAIR1 in FC applications and shows reactivity with human samples.

经测试应用 FC Application Description
经测试反应性 human
免疫原 LAIR1 fusion protein Eg2329 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 leukocyte-associated immunoglobulin-like receptor 1
别名 241805G2, CD305, hLAIR1, LAIR 1, LAIR-1
计算分子量 287 aa, 31 kDa
GenBank蛋白编号BC027899
基因名称 LAIR1
Gene ID (NCBI) 3903
偶联类型 CoraLite®594 Fluorescent Dye
最大激发/发射波长588 nm / 604 nm
形式Liquid
纯化方式Protein A purification
UNIPROT IDQ6GTX8
储存缓冲液 PBS with 0.09% sodium azide and 0.5% BSA, pH 7.3.
储存条件Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

背景介绍

Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1) is a transmembrane glycoprotein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs (PMID: 9285412). LAIR1 is expressed on the majority of human PBMCs, including NK, T, B, monocytes, and dendritic cells, as well as the majority of thymocytes (PMID: 10229813). It functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of NK cells, B cells and T cells. LAIR1 is a collagen receptor (PMID: 16754721). Tumor-expressed collagens can modulate immune cell function through the inhibitory collagen receptor LAIR1 (PMID: 21955987).

实验方案

Product Specific Protocols
FC protocol for CL594 LAIR1 antibody CL594-98326Download protocol
Standard Protocols
Click here to view our Standard Protocols