CoraLite®594-conjugated LAIR1 Monoclonal antibody

LAIR1 Monoclonal Antibody for IF-P

Host / Isotype

Mouse / IgG2a

Reactivity

Human

Applications

IF-P

Conjugate

CoraLite®594 Fluorescent Dye

CloneNo.

1A5D1

Cat No : CL594-67220

Print datasheet

Synonyms

CD305, hLAIR1, LAIR 1, LAIR1



经过测试的应用

Positive IF detected inhuman tonsillitis tissue
For other applications, we recommend the unconjugated version of this antibody, 67220-1-Ig

推荐稀释比

ApplicationDilution
Immunofluorescence (IF)IF : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

CL594-67220 targets LAIR1 in IF applications and shows reactivity with Human samples.

Tested Applications IF-P
Tested Reactivity Human
Immunogen LAIR1 fusion protein Ag14459 种属同源性预测
Host / Isotype Mouse / IgG2a
Class Monoclonal
Type Antibody
Full Name leukocyte-associated immunoglobulin-like receptor 1
Synonyms CD305, hLAIR1, LAIR 1, LAIR1
Calculated Molecular Weight 287 aa, 31 kDa
GenBank Accession NumberBC027899
Gene Symbol LAIR1
Gene ID (NCBI) 3903
RRIDAB_2920100
Conjugate CoraLite®594 Fluorescent Dye
Excitation/Emission Maxima Wavelengths588 nm / 604 nm
Form Liquid
Purification MethodProtein A purification
UNIPROT IDQ6GTX8
Storage Buffer PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3.
Storage ConditionsStore at -20°C. Avoid exposure to light. Aliquoting is unnecessary for -20oC storage.

背景介绍

Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1) is a transmembrane glycoprotein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs (PMID: 9285412). LAIR1 is expressed on the majority of human PBMCs, including NK, T, B, monocytes, and dendritic cells, as well as the majority of thymocytes (PMID: 10229813). It functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of NK cells, B cells and T cells. LAIR1 is a collagen receptor (PMID: 16754721). Tumor-expressed collagens can modulate immune cell function through the inhibitory collagen receptor LAIR1 (PMID: 21955987).

实验方案

Product Specific Protocols
IF protocol for CL594 LAIR1 antibody CL594-67220Download protocol
Standard Protocols
Click here to view our Standard Protocols