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验证数据展示

  • IF Staining of THP-1 using CL488-84677-4

    IF Staining of THP-1 using CL488-84677-4

    Immunofluorescent analysis of (4% PFA) fixed THP-1 cells using CoraLite® Plus 488 LAIR1 antibody (CL488-84677-4, Clone: 241805C2 ) at dilution of 1:200.

CoraLite® Plus 488-conjugated LAIR1 Recombinant antibody

LAIR1 Recombinant Antibody for IF/ICC
Cat No. CL488-84677-4

产品说明书

CloneNo. 241805C2

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

IF/ICC

别名

241805C2, CD305, hLAIR1, LAIR 1, LAIR-1

缓冲液配方:  PBS and Azide
PBS and Azide
偶联物:  CoraLite® Plus 488
规格价格库存

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经过测试的应用

Positive IF/ICC detected inTHP-1 cells
For other applications, we recommend the unconjugated version of this antibody, 84677-4-PBS

推荐稀释比

应用推荐稀释比
Immunofluorescence (IF)/ICCIF/ICC : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

CL488-84677-4 targets LAIR1 in IF/ICC applications and shows reactivity with human samples.

经测试应用 IF/ICC Application Description
经测试反应性 human
免疫原 LAIR1 fusion protein Eg2329 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 leukocyte-associated immunoglobulin-like receptor 1
别名 241805C2, CD305, hLAIR1, LAIR 1, LAIR-1
计算分子量 287 aa, 31 kDa
GenBank蛋白编号BC027899
基因名称 LAIR1
Gene ID (NCBI) 3903
偶联类型 CoraLite® Plus 488 Fluorescent Dye
最大激发/发射波长493 nm / 522 nm
形式Liquid
纯化方式Protein A purification
UNIPROT IDQ6GTX8
储存缓冲液 PBS with 50% glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3.
储存条件Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1) is a transmembrane glycoprotein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs (PMID: 9285412). LAIR1 is expressed on the majority of human PBMCs, including NK, T, B, monocytes, and dendritic cells, as well as the majority of thymocytes (PMID: 10229813). It functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of NK cells, B cells and T cells. LAIR1 is a collagen receptor (PMID: 16754721). Tumor-expressed collagens can modulate immune cell function through the inhibitory collagen receptor LAIR1 (PMID: 21955987).

实验方案

Product Specific Protocols
IF protocol for CL Plus 488 LAIR1 antibody CL488-84677-4Download protocol
Standard Protocols
Click here to view our Standard Protocols