• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

验证数据展示

  • FC experiment of human peripheral blood leukocytes using 98281-1-RR (same clone as 98281-1-PBS)

    FC experiment of human peripheral blood leukocytes using 98281-1-RR (same clone as 98281-1-PBS)

    1x10^6 human peripheral blood leukocytes were surface stained with 0.25 ug Anti-Human CD161/KLRB1 Rabbit RecAb (98281-1-RR, Clone: 242140H5) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98281-1-PBS in a different storage buffer formulation.

  • FC experiment of human peripheral blood leukocytes using 98281-1-RR (same clone as 98281-1-PBS)

    FC experiment of human peripheral blood leukocytes using 98281-1-RR (same clone as 98281-1-PBS)

    1x10^6 human peripheral blood leukocytes were surface stained with 0.25 ug Anti-Human CD161/KLRB1 Rabbit RecAb (98281-1-RR, Clone:242140H5) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were then stained with CoraLite® Plus 647 Anti-Human NCAM1/CD56. Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98281-1-PBS in a different storage buffer formulation.

  • FC experiment of human peripheral blood leukocytes using 98281-1-RR (same clone as 98281-1-PBS)

    FC experiment of human peripheral blood leukocytes using 98281-1-RR (same clone as 98281-1-PBS)

    1x10^6 human peripheral blood leukocytes were surface stained with 0.25 ug Anti-Human CD161/KLRB1 Rabbit RecAb (98281-1-RR, Clone: 242140H5) (red) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98281-1-PBS in a different storage buffer formulation.

Anti-Human KLRB1/CD161 Rabbit Recombinant Antibody, PBS Only

KLRB1/CD161 Uni-rAbTM Recombinant Antibody for FC
Cat No. 98281-1-PBS

产品说明书

CloneNo. 242140H5

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

FC

别名

CD161, 242140H5, HNKR-P1a, hNKR P1A, C-type lectin domain family 5 member B

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

点击咨询售前客服

点击咨询售后客服

产品信息

98281-1-PBS targets KLRB1/CD161 in FC applications and shows reactivity with human samples.

经测试应用 FC Application Description
经测试反应性 human
免疫原 Recombinant protein 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 killer cell lectin-like receptor subfamily B, member 1
别名 CD161, 242140H5, HNKR-P1a, hNKR P1A, C-type lectin domain family 5 member B
计算分子量25 kDa
GenBank蛋白编号NM_002258.3
基因名称 CD161
Gene ID (NCBI) 3820
ENSEMBL Gene IDENSG00000111796
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purfication
UNIPROT IDQ12918
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

CD161, also known as KLRB1 or NKR-P1A, is a type II transmembrane C-type lectin-like receptor and is expressed on the cell membrane as disulfide-linked homodimer (PMID: 8077657). It is expressed by the majority of NK cells and subsets of peripheral T cells, including both CD4+ and CD8+ T cells, and is expressed preferentially on adult T cells with a "memory" antigenic phenotype (PMID: 8077657; 22566826). Expression of CD161 correlates with the cytotoxic function of CD16+ NK cells, and ligation of CD161 with its ligand LLT1 inhibits NK cell cytotoxicity and cytokine secretion (PMID: 29686665).