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验证数据展示

  • IP experiment of Jurkat using 33139-1-AP (same clone as 33139-1-PBS)

    IP experiment of Jurkat using 33139-1-AP (same clone as 33139-1-PBS)

    IP result of anti-KIF18B (IP:33139-1-AP, 4ug; Detection:33139-1-AP 1:400) with Jurkat cells lysate 1360 ug. This data was developed using the same antibody clone with 33139-1-PBS in a different storage buffer formulation.

  • IF Staining of Jurkat using 33139-1-AP (same clone as 33139-1-PBS)

    IF Staining of Jurkat using 33139-1-AP (same clone as 33139-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed Jurkat cells using KIF18B antibody (33139-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 33139-1-PBS in a different storage buffer formulation.

  • IF Staining of U2OS using 33139-1-AP (same clone as 33139-1-PBS)

    IF Staining of U2OS using 33139-1-AP (same clone as 33139-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed U2OS cells using KIF18B antibody (33139-1-AP) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2), CL594-Phalloidin (red). This data was developed using the same antibody clone with 33139-1-PBS in a different storage buffer formulation.

KIF18B Polyclonal antibody, PBS Only

KIF18B Polyclonal Antibody for IF/ICC, IP, Indirect ELISA
Cat No. 33139-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

IF/ICC, IP, Indirect ELISA

别名

Kinesin-like protein KIF18B

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

33139-1-PBS targets KIF18B in IF/ICC, IP, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 IF/ICC, IP, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag36663

Product name: Recombinant human KIF18B protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-110 aa of BC136590

Sequence: MAVEDSTLQVVVRVRPPTPRELDSQRRPVVQVVDERVLVFNPEEPDGGFPGLKWGGTHDGPKKKGKDLTFVFDRVFGEAATQQDVFQHTTHSVLDSFLQGYNCSVFAYGA

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 kinesin family member 18B
别名 Kinesin-like protein KIF18B
计算分子量852 aa, 93 kDa/833 aa, 91 kDa
观测分子量100 kDa
GenBank蛋白编号BC136590
基因名称 KIF18B
Gene ID (NCBI) 146909
RRIDAB_3742867
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity Purification
UNIPROT IDQ86Y91
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

KIF18B is a key member of the kinesin-8 family, involved in regulating various physiological processes such as microtubule length, spindle assembly, and chromosome alignment. This article briefly introduces the structure and physiological functions of KIF18B, examines its role in malignant tumors, and the associated carcinogenic signaling pathways such as PI3K/AKT, Wnt/β-catenin, and mTOR pathways. Research indicates that the upregulation of KIF18B enhances tumor malignancy and resistance to radiotherapy and chemotherapy. KIF18B could become a new target for anticancer drugs, offering significant potential for the treatment of malignant tumors and reducing chemotherapy resistance (PMID: 39259333).

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