验证数据展示
产品信息
32467-1-PBS targets KIAA1024 in WB, Indirect ELISA applications and shows reactivity with human, rat samples.
| 经测试应用 | WB, Indirect ELISA Application Description |
| 经测试反应性 | human, rat |
| 免疫原 |
CatNo: Ag38274 Product name: Recombinant human KIAA1024 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 742-891 aa of NM_015206.2 Sequence: VGLNEEEIKDTGPGDNKDWHRKSKEADRQYDIPPQHRLPKQPKDGFLVEQVFSPHPYPASLKAHMKSNPLYTDMRLTELAEVKRGQPSWTIEEYARNAGDKGKLTALDLQTQESLNPNNLEYWMEDIYTPGYDSLLKRKEAEFRRAKVCK 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | KIAA1024 |
| 别名 | Major intrinsically disordered Notch2-binding receptor 1, Membrane integral NOTCH2-associated receptor 1, MINAR1, Ubiquitination and mTOR signaling protein, UBTOR |
| 计算分子量 | 103kDa，916aa |
| 观测分子量 | 102 kDa |
| GenBank蛋白编号 | NM_015206.2 |
| 基因名称 | KIAA1024 |
| Gene ID (NCBI) | 23251 |
| RRID | AB_3742619 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity Purification |
| UNIPROT ID | Q9UPX6 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
KIAA1024 negatively regulates the activities of mTORC1 and mTORC2 by stabilizing the MTOR complex inhibitor DEPTOR, thus inhibiting cell overgrowth. In cultured hippocampal neurons and PC12 cells, knocking down KIAA1024 can activate mTOR signal and promote neurite outgrowth. However, in zebrafish and mouse transplanted tumor models, deletion of this gene will significantly enhance the tumor formation induced by HRAS(G12V), suggesting that it has antitumor effect.
